[1-(4-Fluoro-3-morpholin-4-yl-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine

Base Information

• Chemical Name: [1-(4-Fluoro-3-morpholin-4-yl-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine
• CAS No.: 591742-63-1
• Molecular Formula: C₂₀H₂₃FN₂O
• Molecular Weight: 326.414

Synonyms:[1-(4-Fluoro-3-morpholin-4-yl-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine

Chemical Property of [1-(4-Fluoro-3-morpholin-4-yl-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine

Chemical Property:

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Technology Process of [1-(4-Fluoro-3-morpholin-4-yl-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine

There total 2 articles about [1-(4-Fluoro-3-morpholin-4-yl-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluoro-3-bromoacetophenone (1007-15-4) → [1-(4-Fluoro-3-morpholin-4-yl-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine (591742-63-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / Pd(OAc)2; Cs₂CO₃; di(tert-butyl)(2-biphenyl)phosphine / benzene / 17 h / 80 °C

2: TiCl₄; Et₃N / toluene / 12 h

With palladium diacetate; titanium tetrachloride; caesium carbonate; triethylamine; johnphos; In toluene; benzene;

DOI:10.1016/S0960-894X(03)00240-3

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) + 1-(4-fluoro-3-morpholin-4-yl-phenyl)-ethanone (519137-75-8) → [1-(4-Fluoro-3-morpholin-4-yl-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine (591742-63-1)

Guidance literature:

With titanium tetrachloride; triethylamine; In toluene; for 12h;

DOI:10.1016/S0960-894X(03)00240-3

Reference yield:

[1-(4-Fluoro-3-morpholin-4-yl-phenyl)-eth-(E)-ylidene]-((S)-1-phenyl-ethyl)-amine (591742-63-1) → [(S)-1-(4-Fluoro-3-morpholin-4-yl-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amine (591742-64-2) + [(R)-1-(4-Fluoro-3-morpholin-4-yl-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amine

Guidance literature:

With hydrogen; Ra-Ni; In methanol; for 2h; under 1551.44 Torr;

DOI:10.1016/S0960-894X(03)00240-3

upstream raw materials:

(S)-1-phenyl-ethylamine

1-(4-fluoro-3-morpholin-4-yl-phenyl)-ethanone

4-fluoro-3-bromoacetophenone

Downstream raw materials:

[(S)-1-(4-Fluoro-3-morpholin-4-yl-phenyl)-ethyl]-((S)-1-phenyl-ethyl)-amine

(S)-1-(4-fluoro-3-morpholin-4-yl-phenyl)ethylamine

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