(3'S)-3'-tert-butoxycarbonylamino-2',3'-dideoxy-2'-methylidene-5'-O-tritylcytidine

Base Information

Chemical Name:(3'S)-3'-tert-butoxycarbonylamino-2',3'-dideoxy-2'-methylidene-5'-O-tritylcytidine
CAS No.:142688-44-6
Molecular Formula:C₃₄H₃₆N₄O₅
Molecular Weight:580.684
Hs Code.:

Synonyms:(3'S)-3'-tert-butoxycarbonylamino-2',3'-dideoxy-2'-methylidene-5'-O-tritylcytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3'S)-3'-tert-butoxycarbonylamino-2',3'-dideoxy-2'-methylidene-5'-O-tritylcytidine

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Technology Process of (3'S)-3'-tert-butoxycarbonylamino-2',3'-dideoxy-2'-methylidene-5'-O-tritylcytidine

There total 11 articles about (3'S)-3'-tert-butoxycarbonylamino-2',3'-dideoxy-2'-methylidene-5'-O-tritylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 142688-43-5
(3'S)-3'-tert-butoxycarbonylamino-2',3'-dideoxy-2'-methylidene-5'-O-trityluridine

: 142688-44-6
(3'S)-3'-tert-butoxycarbonylamino-2',3'-dideoxy-2'-methylidene-5'-O-tritylcytidine

Guidance literature:: With dmap; ammonium hydroxide; Triphenylsilyl chloride; triethylamine; In acetonitrile; for 12h; Ambient temperature;
DOI:10.1016/S0040-4020(01)80786-9

Reference yield:

: 142688-37-7
Methanesulfonic acid (2R,3S,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-methylene-2-trityloxymethyl-tetrahydro-furan-3-yl ester

: 142688-44-6
(3'S)-3'-tert-butoxycarbonylamino-2',3'-dideoxy-2'-methylidene-5'-O-tritylcytidine

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / ethanol / 4 h / Ambient temperature

2: 73 percent / NCS, Et₃N / tetrahydrofuran; methanol / 3 h / -78 - -21 °C

3: 90 percent / TPSCl, Et₃N, DMAP, 28percent NH₄OH / acetonitrile / 12 h / Ambient temperature

With dmap; ammonium hydroxide; N-chloro-succinimide; Triphenylsilyl chloride; triethylamine; In tetrahydrofuran; methanol; ethanol; acetonitrile;
DOI:10.1016/S0040-4020(01)80786-9

Reference yield:

: 4248-19-5
tert-butyl carbazate

: 142688-44-6
(3'S)-3'-tert-butoxycarbonylamino-2',3'-dideoxy-2'-methylidene-5'-O-tritylcytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / NCS, Et₃N / tetrahydrofuran; methanol / 3 h / -78 - -21 °C

2: 90 percent / TPSCl, Et₃N, DMAP, 28percent NH₄OH / acetonitrile / 12 h / Ambient temperature

With dmap; ammonium hydroxide; N-chloro-succinimide; Triphenylsilyl chloride; triethylamine; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/S0040-4020(01)80786-9