6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-methoxy-5-pivaloylamino-4H-1-benzopyran-4-one

Base Information

Chemical Name:6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-methoxy-5-pivaloylamino-4H-1-benzopyran-4-one
CAS No.:165180-08-5
Molecular Formula:C₂₆H₂₇F₃N₂O₅
Molecular Weight:504.506
Hs Code.:

Synonyms:6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-methoxy-5-pivaloylamino-4H-1-benzopyran-4-one

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Chemical Property of 6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-methoxy-5-pivaloylamino-4H-1-benzopyran-4-one

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Technology Process of 6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-methoxy-5-pivaloylamino-4H-1-benzopyran-4-one

There total 6 articles about 6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-methoxy-5-pivaloylamino-4H-1-benzopyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 165179-95-3
6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-hydroxy-5-pivaloylamino-4H-1-benzopyran-4-one

: 74-88-4
methyl iodide

: 165180-08-5
6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-methoxy-5-pivaloylamino-4H-1-benzopyran-4-one

Guidance literature:: With potassium carbonate; In acetone; for 0.666667h; Heating;
DOI:10.1021/jm970728z

Reference yield:

: 152835-78-4
ethyl 3,5-difluoro-6-(N-pivaloylamino)-2-(2-tetrahydropyranyloxy)benzoate

: 165180-08-5
6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-methoxy-5-pivaloylamino-4H-1-benzopyran-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA, 2) trimethylborate, 3.) AcOH, 30percent aq. H₂O₂

2: 93 percent / iPr₂NEt, / CH₂Cl₂ / 0.5 h / Ambient temperature

3: NaH / dioxane; toluene / 2 h / Heating

4: conc. aq. HCl / ethanol / 14 h / Ambient temperature

5: 78 percent / K₂CO₃ / acetone / 0.67 h / Heating

With hydrogenchloride; Trimethyl borate; dihydrogen peroxide; sodium hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In 1,4-dioxane; ethanol; dichloromethane; acetone; toluene;
DOI:10.1021/jm970728z

Reference yield:

: 152835-84-2
ethyl 3,5-difluoro-6-pivaloylamino-2-(2-tetrahydropyranyloxy)-4-trimethylsilylbenzoate

: 165180-08-5
6,8-difluoro-2-(3-fluoro-4-pivaloylaminophenyl)-7-methoxy-5-pivaloylamino-4H-1-benzopyran-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / TBAF / tetrahydrofuran / 0.5 h / 0 °C

2: 1.) LDA, 2) trimethylborate, 3.) AcOH, 30percent aq. H₂O₂

3: 93 percent / iPr₂NEt, / CH₂Cl₂ / 0.5 h / Ambient temperature

4: NaH / dioxane; toluene / 2 h / Heating

5: conc. aq. HCl / ethanol / 14 h / Ambient temperature

6: 78 percent / K₂CO₃ / acetone / 0.67 h / Heating

With hydrogenchloride; Trimethyl borate; tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetone; toluene;
DOI:10.1021/jm970728z