ethyl 4-(4-chlorophenoxy)-2,6-bis(trifluoromethyl)pyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl 4-(4-chlorophenoxy)-2,6-bis(trifluoromethyl)pyrimidine-5-carboxylate
CAS No.:121562-22-9
Molecular Formula:C₁₅H₉ClF₆N₂O₃
Molecular Weight:414.691
Hs Code.:

Synonyms:ethyl 4-(4-chlorophenoxy)-2,6-bis(trifluoromethyl)pyrimidine-5-carboxylate

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Chemical Property of ethyl 4-(4-chlorophenoxy)-2,6-bis(trifluoromethyl)pyrimidine-5-carboxylate

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Technology Process of ethyl 4-(4-chlorophenoxy)-2,6-bis(trifluoromethyl)pyrimidine-5-carboxylate

There total 3 articles about ethyl 4-(4-chlorophenoxy)-2,6-bis(trifluoromethyl)pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 121562-18-3
ethyl 2,6-bis(trifluoromethyl)-4-chloropyrimidine-5-carboxylate

: 106-48-9,82344-39-6
4-chloro-phenol

: 121562-22-9
ethyl 4-(4-chlorophenoxy)-2,6-bis(trifluoromethyl)pyrimidine-5-carboxylate

Guidance literature:: With potassium carbonate; In toluene; Heating;
DOI:10.1002/jhet.5570260102

Reference yield:

: 121562-14-9
ethyl 2,6-bis(trifluoromethyl)-4-hydroxypyrimidine-5-carboxylate

: 121562-22-9
ethyl 4-(4-chlorophenoxy)-2,6-bis(trifluoromethyl)pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / POCl₃ / 30 h / Heating

2: 88 percent / K₂CO₃ / toluene / Heating

With potassium carbonate; trichlorophosphate; In toluene;
DOI:10.1002/jhet.5570260102

Reference yield:

: 105-53-3
diethyl malonate

: 121562-22-9
ethyl 4-(4-chlorophenoxy)-2,6-bis(trifluoromethyl)pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) t-BuOK / 1) THF, 60 deg C; 2) THF

2: 62 percent / POCl₃ / 30 h / Heating

3: 88 percent / K₂CO₃ / toluene / Heating

With potassium tert-butylate; potassium carbonate; trichlorophosphate; In toluene;
DOI:10.1002/jhet.5570260102