(R_S)-(+)-2-[N-(p-toluenesulfinamido)]-3-(S)-fluoro-3-phenylpropionitrile

Base Information

• Chemical Name: (R_S)-(+)-2-[N-(p-toluenesulfinamido)]-3-(S)-fluoro-3-phenylpropionitrile
• CAS No.: 247039-05-0
• Molecular Formula: C₁₆H₁₅FN₂OS
• Molecular Weight: 302.372

Synonyms:(R_S)-(+)-2-[N-(p-toluenesulfinamido)]-3-(S)-fluoro-3-phenylpropionitrile

Chemical Property of (R_S)-(+)-2-[N-(p-toluenesulfinamido)]-3-(S)-fluoro-3-phenylpropionitrile

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of (R_S)-(+)-2-[N-(p-toluenesulfinamido)]-3-(S)-fluoro-3-phenylpropionitrile

There total 7 articles about (R_S)-(+)-2-[N-(p-toluenesulfinamido)]-3-(S)-fluoro-3-phenylpropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

diethylaluminium cyanide (5804-85-3) + (RS)-(-)-N-(2(S)-2-fluorophenylacetylidene)-p-toluenesulfinamide → (RS)-(+)-2-[N-(p-toluenesulfinamido)]-3-(S)-fluoro-3-phenylpropionitrile (247039-05-0)

Guidance literature:

With isopropyl alcohol; In tetrahydrofuran; at -78 - 20 ℃; for 12h;

DOI:10.1021/jo990947n

Reference yield:

(R)-p-toluenesulfinamide (247089-85-6) → (RS)-(+)-2-[N-(p-toluenesulfinamido)]-3-(S)-fluoro-3-phenylpropionitrile (247039-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

2: 78 percent / i-PrOH / tetrahydrofuran / 12 h / -78 - 20 °C

With 4 A molecular sieve; isopropyl alcohol; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Addition;

DOI:10.1021/jo990947n

Reference yield:

α-fluorobenzeneacetaldehyde (13344-76-8) → (RS)-(+)-2-[N-(p-toluenesulfinamido)]-3-(S)-fluoro-3-phenylpropionitrile (247039-05-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

2: 78 percent / i-PrOH / tetrahydrofuran / 12 h / -78 - 20 °C

With 4 A molecular sieve; isopropyl alcohol; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Addition;

DOI:10.1021/jo990947n

upstream raw materials:

diethylaluminium cyanide

α-fluorobenzeneacetaldehyde

fluoro-phenyl-acetic acid ethyl ester

(S)-(+)-2-fluorophenylacetaldehyde

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