[1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzylamine

Base Information

Chemical Name:[1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzylamine
CAS No.:306967-87-3
Molecular Formula:C₂₂H₂₇N₃O₄
Molecular Weight:397.474
Hs Code.:

Synonyms:[1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzylamine

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Technology Process of [1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzylamine

There total 4 articles about [1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 552-89-6
2-nitro-benzaldehyde

: 89483-75-0
1-[1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-yl]methylamine

: 306967-87-3
[1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzylamine

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 1.5h; Heating;
DOI:10.1021/jm991121g

Reference yield:

: 1094-91-3
2-(toluene-4-sulfonyloxymethyl)-2,3-dihydro-benzo[1,4]dioxine

: 306967-87-3
[1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / 16 h / 120 °C

2: 88 percent / LiAlH₄ / tetrahydrofuran

3: 50 percent / NaBH₄ / ethanol / 1.5 h / Heating

With sodium tetrahydroborate; lithium aluminium tetrahydride; In tetrahydrofuran; ethanol; 1: Alkylation / 2: Reduction / 3: reductive alkylation;
DOI:10.1021/jm991121g

Reference yield:

: 39546-32-2
4-carboxamidopiperidine

: 306967-87-3
[1-(2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-ylmethyl]-2-nitrobenzylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / 16 h / 120 °C

2: 88 percent / LiAlH₄ / tetrahydrofuran

3: 50 percent / NaBH₄ / ethanol / 1.5 h / Heating

With sodium tetrahydroborate; lithium aluminium tetrahydride; In tetrahydrofuran; ethanol; 1: Alkylation / 2: Reduction / 3: reductive alkylation;
DOI:10.1021/jm991121g