1,1-dimethylethyl 3-[5-(5-{3-cyano-4-[(cyclopropylmethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoate

Base Information

Chemical Name:1,1-dimethylethyl 3-[5-(5-{3-cyano-4-[(cyclopropylmethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoate
CAS No.:1192829-98-3
Molecular Formula:C₂₉H₂₈N₄O₄
Molecular Weight:496.566
Hs Code.:

Synonyms:1,1-dimethylethyl 3-[5-(5-{3-cyano-4-[(cyclopropylmethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,1-dimethylethyl 3-[5-(5-{3-cyano-4-[(cyclopropylmethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1,1-dimethylethyl 3-[5-(5-{3-cyano-4-[(cyclopropylmethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoate

There total 9 articles about 1,1-dimethylethyl 3-[5-(5-{3-cyano-4-[(cyclopropylmethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192829-80-3
3-cyano-4-[(cyclopropylmethyl)oxy]benzoyl chloride

: 1192829-85-8
1,1-dimethylethyl 3-{5-[(hydroxyamino)(imino)methyl]-1-isoquinolinyl}propanoate

: 1192829-98-3
1,1-dimethylethyl 3-[5-(5-{3-cyano-4-[(cyclopropylmethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 100 ℃; for 17.5h; Inert atmosphere;

Reference yield:

: 34784-04-8
5-bromoisoquinoline

: 1192829-98-3
1,1-dimethylethyl 3-[5-(5-{3-cyano-4-[(cyclopropylmethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: aluminum (III) chloride / dichloromethane / 3.08 h / 30 °C

2: sodium hydride / N,N-dimethyl-formamide / 3.83 h / -10 - 20 °C / Inert atmosphere

3: 1,1'-bis-(diphenylphosphino)ferrocene; sodium carbonate; potassium hexacyanoferrate(III) / palladium diacetate / DMA / 120 °C

4: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 5 h / 60 °C

5: triethylamine / N,N-dimethyl-formamide / 17.5 h / 0 - 100 °C / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; sodium carbonate; triethylamine; potassium hexacyanoferrate(III); aluminum (III) chloride; palladium diacetate; In DMA; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1192829-79-0
3-cyano-4-(cyclopropylmethoxy)benzoic acid

: 1192829-98-3
1,1-dimethylethyl 3-[5-(5-{3-cyano-4-[(cyclopropylmethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 17.5 h / 0 - 100 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;