((2S,5S)-2-{5-[2-(4-{2-[(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-phenyl)-quinoxalin-6-yl]-1H-imidazol-2-yl}-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl)-carbamic acid methyl ester

Base Information

Chemical Name:((2S,5S)-2-{5-[2-(4-{2-[(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-phenyl)-quinoxalin-6-yl]-1H-imidazol-2-yl}-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl)-carbamic acid methyl ester
CAS No.:1399845-36-3
Molecular Formula:C₄₅H₄₆N₁₀O₆
Molecular Weight:822.924
Hs Code.:

((2S,5S)-2-{5-[2-(4-{2-[(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-phenyl)-quinoxalin-6-yl]-1H-imidazol-2-yl}-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl)-carbamic acid methyl ester

Synonyms:((2S,5S)-2-{5-[2-(4-{2-[(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-phenyl)-quinoxalin-6-yl]-1H-imidazol-2-yl}-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl)-carbamic acid methyl ester

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Chemical Property of ((2S,5S)-2-{5-[2-(4-{2-[(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-phenyl)-quinoxalin-6-yl]-1H-imidazol-2-yl}-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl)-carbamic acid methyl ester

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Technology Process of ((2S,5S)-2-{5-[2-(4-{2-[(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-phenyl)-quinoxalin-6-yl]-1H-imidazol-2-yl}-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl)-carbamic acid methyl ester

There total 9 articles about ((2S,5S)-2-{5-[2-(4-{2-[(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-phenyl)-quinoxalin-6-yl]-1H-imidazol-2-yl}-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl)-carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.5%

: (2S,5S)-2-(2-(4-(2-((S)-1-((S)-2-(methoxycarbonylamino)-3-methyl butanoyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)phenyl)quinoxalin-6-yl)-2-oxoethyl 5-(methoxy carbonyl amino)-4-oxo-1,2,4,5,6,7-hexahydroazepino[3,2,1-hi]indole-2-carboxylate

: 1399845-36-3
((2S,5S)-2-{5-[2-(4-{2-[(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-phenyl)-quinoxalin-6-yl]-1H-imidazol-2-yl}-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl)-carbamic acid methyl ester

Guidance literature:: With ammonium acetate; In 1,4-dioxane; dichloromethane; at 110 ℃; for 6h; Sealed tube;

Reference yield:

: 55687-02-0
6-bromo-2-chloro-quinoxaline

: 1399845-36-3
((2S,5S)-2-{5-[2-(4-{2-[(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-phenyl)-quinoxalin-6-yl]-1H-imidazol-2-yl}-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 80 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 6 h / 80 °C / Inert atmosphere

3: N-Bromosuccinimide / water; tetrahydrofuran / 1 h / 0 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

5: ammonium acetate / dichloromethane; 1,4-dioxane / 6 h / 110 °C / Sealed tube

With N-Bromosuccinimide; ammonium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1196-57-2,144499-26-3
2-hydroxyquinoxaline

: 1399845-36-3
((2S,5S)-2-{5-[2-(4-{2-[(S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-phenyl)-quinoxalin-6-yl]-1H-imidazol-2-yl}-4-oxo-1,2,4,5,6,7-hexahydro-azepino[3,2,1-hi]indol-5-yl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: bromine; sulfuric acid; silver sulfate / 2.5 h / 10 - 45 °C

2: trichlorophosphate / N,N-dimethyl-formamide / 1.5 h / 80 - 120 °C

3: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 80 °C / Inert atmosphere

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 6 h / 80 °C / Inert atmosphere

5: N-Bromosuccinimide / water; tetrahydrofuran / 1 h / 0 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

7: ammonium acetate / dichloromethane; 1,4-dioxane / 6 h / 110 °C / Sealed tube

With N-Bromosuccinimide; sulfuric acid; ammonium acetate; bromine; caesium carbonate; silver sulfate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;