methyl {(2S)-1-[(2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

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Chemical Name:methyl {(2S)-1-[(2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate
CAS No.:1261072-54-1
Molecular Formula:C₂₈H₂₉BrN₆O₃
Molecular Weight:577.481
Hs Code.:

Synonyms:methyl {(2S)-1-[(2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

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Chemical Property of methyl {(2S)-1-[(2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

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Technology Process of methyl {(2S)-1-[(2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

There total 14 articles about methyl {(2S)-1-[(2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 55687-02-0
6-bromo-2-chloro-quinoxaline

: 1228553-33-0
[(S)-2-methyl-1-((S)-2-{5-[4-(4,4,5,5 tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-imidazol-2-yl}-pyrrolidine-1-carbonyl)-propyl]-carbamic acid methyl ester

: 1261072-54-1
methyl {(2S)-1-[(2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;

Reference yield:

: 6-bromo-2-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)quinoxaline hydrochloride

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1261072-54-1
methyl {(2S)-1-[(2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 55687-02-0
6-bromo-2-chloro-quinoxaline

: 1261072-54-1
methyl {(2S)-1-[(2S)-2-{5-[4-(6-bromoquinoxalin-2-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 30 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 10 - 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C

With hydrogenchloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane; N,N-dimethyl-formamide;