1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN.

Base Information

• Chemical Name: 1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN.
• CAS No.: 283173-83-1
• Molecular Formula: C₁₁H₁₃BrFN
• Molecular Weight: 258.133
• Hs Code.: 2933990090
• Mol file: 283173-83-1.mol

Synonyms:1-(4-Bromo-2-fluorobenzyl)pyrrolidine

Chemical Property of 1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN.

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.574
• Boiling Point: 281.627°C at 760 mmHg
• Flash Point: 124.124°C
• PSA: 3.24000
• Density: 1.446g/cm³
• LogP: 3.12190

Purity/Quality:

95% ^*data from raw suppliers

1-[(4-Bromo-2-fluorophenyl)methyl]pyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN.

There total 2 articles about 1-(4-BROMO-2-FLUOROBENZYL)PYRROLIDINE, 98% MIN. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyrrolidine (123-75-1) + 4-bromo-2-fluorobenzaldehyde (57848-46-1) → 1-(4-bromo-2-fluorobenzyl)pyrrolidine (283173-83-1)

Guidance literature:

pyrrolidine; 4-bromo-2-fluorobenzaldehyde; In dichloromethane; for 3h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

DOI:10.1021/acs.jmedchem.1c01102

Reference yield: 90.0%

pyrrolidine (123-75-1) + 4-bromo-2-fluorobenzyl bromide (76283-09-5) → 1-(4-bromo-2-fluorobenzyl)pyrrolidine (283173-83-1)

Guidance literature:

pyrrolidine; 4-bromo-2-fluorobenzyl bromide; In acetonitrile; at 10 - 20 ℃; for 4h;

With sodium carbonate; In water; acetonitrile;

Reference yield:

1-(4-bromo-2-fluorobenzyl)pyrrolidine (283173-83-1) → 5-chloro-N-(2-(3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl)pyridin-4-yl)-2-methoxypyridine-3-sulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 6 h / 100 °C / Microwave irradiation; Inert atmosphere

2: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 0.75 h / 100 °C / Microwave irradiation; Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium carbonate; In 1,4-dioxane;

upstream raw materials:

pyrrolidine

4-bromo-2-fluorobenzyl bromide

4-bromo-2-fluorobenzaldehyde

Refernces

• 1、 -. "CHEMICAL COMPOUNDS AS INHIBITORS OF KINASE ACTIVITY". Page/Page column 88-89. . Retrieved 2017/09/05.
• 2、 -. "HISTAMINE-3 RECEPTOR ANTAGONISTS". Page/Page column 34-35. . Retrieved 2010/11/27.