(±)-4-methoxybenzyl 3-(2-bromo-4,5-dimethoxybenzyl)-1-methyl-2-oxoindoline-3-carboxylate

Base Information

Chemical Name:(±)-4-methoxybenzyl 3-(2-bromo-4,5-dimethoxybenzyl)-1-methyl-2-oxoindoline-3-carboxylate
CAS No.:1431885-15-2
Molecular Formula:C₂₇H₂₆BrNO₆
Molecular Weight:540.411
Hs Code.:

Synonyms:(±)-4-methoxybenzyl 3-(2-bromo-4,5-dimethoxybenzyl)-1-methyl-2-oxoindoline-3-carboxylate

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Chemical Property of (±)-4-methoxybenzyl 3-(2-bromo-4,5-dimethoxybenzyl)-1-methyl-2-oxoindoline-3-carboxylate

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Technology Process of (±)-4-methoxybenzyl 3-(2-bromo-4,5-dimethoxybenzyl)-1-methyl-2-oxoindoline-3-carboxylate

There total 4 articles about (±)-4-methoxybenzyl 3-(2-bromo-4,5-dimethoxybenzyl)-1-methyl-2-oxoindoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₈BrNO₆

: 1431885-15-2
(±)-4-methoxybenzyl 3-(2-bromo-4,5-dimethoxybenzyl)-1-methyl-2-oxoindoline-3-carboxylate

Guidance literature:: With potassium tert-butylate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dimethyl sulfoxide; at 20 - 100 ℃; Inert atmosphere;
DOI:10.1021/ol400899e

Reference yield:

: 98044-10-1
mono-p-methoxybenzyl malonate

: 1431885-15-2
(±)-4-methoxybenzyl 3-(2-bromo-4,5-dimethoxybenzyl)-1-methyl-2-oxoindoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide; triethylamine / tetrahydrofuran / 0.33 h / 0 - 20 °C / Inert atmosphere

2.1: potassium tert-butylate / dimethyl sulfoxide / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium tert-butylate / dimethyl sulfoxide / 20 - 100 °C / Inert atmosphere

With potassium tert-butylate; triethylamine; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/ol400899e

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 1431885-15-2
(±)-4-methoxybenzyl 3-(2-bromo-4,5-dimethoxybenzyl)-1-methyl-2-oxoindoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 110 °C / Inert atmosphere

2.1: dicyclohexyl-carbodiimide; triethylamine / tetrahydrofuran / 0.33 h / 0 - 20 °C / Inert atmosphere

3.1: potassium tert-butylate / dimethyl sulfoxide / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium tert-butylate / dimethyl sulfoxide / 20 - 100 °C / Inert atmosphere

With potassium tert-butylate; triethylamine; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1021/ol400899e