4-(3-chlorophenyl)-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine hydrochloride

Base Information

Chemical Name:4-(3-chlorophenyl)-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine hydrochloride
CAS No.:925917-93-7
Molecular Formula:C₁₉H₁₈ClN₃O₂*ClH
Molecular Weight:392.285
Hs Code.:

Synonyms:4-(3-chlorophenyl)-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine hydrochloride

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Chemical Property of 4-(3-chlorophenyl)-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine hydrochloride

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Technology Process of 4-(3-chlorophenyl)-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine hydrochloride

There total 9 articles about 4-(3-chlorophenyl)-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 925979-47-1
4-(3-chlorophenyl)-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine

: 925917-93-7
4-(3-chlorophenyl)-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether;

Reference yield:

: 871819-39-5
2-methoxycarbonylmethyl-1-methyl-1H-pyrrole-3-carboxylic acid methyl ester

: 925917-93-7
4-(3-chlorophenyl)-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran / 20 °C

2.1: ammonium acetate / methanol / 2 h / Heating / reflux

3.1: sodium t-butanolate / N,N-dimethyl-formamide / 0.08 h / 160 °C / Microwave

4.1: O-phenyl phosphorodichloridate / 0.5 h / 180 °C

5.1: sodium hydroxide; water / methanol / 4 h / Heating / reflux

5.2: pH 1

6.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 - 80 °C

8.1: hydrogenchloride / methanol; diethyl ether

With N-ethylmorpholine;; hydrogenchloride; sodium hydroxide; ammonium acetate; water; sodium hydride; sodium carbonate; benzotriazol-1-ol; O-phenyl phosphorodichloridate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium t-butanolate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; water; N,N-dimethyl-formamide; 7.1: Suzuki Coupling;

Reference yield:

: 871819-42-0
1-methyl-4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-7-carboxylic acid methyl ester

: 925917-93-7
4-(3-chlorophenyl)-1-methyl-7-(4-morpholinylcarbonyl)-1H-pyrrolo[3,2-c]pyridine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: O-phenyl phosphorodichloridate / 0.5 h / 180 °C

2.1: sodium hydroxide; water / methanol / 4 h / Heating / reflux

2.2: pH 1

3.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 - 80 °C

5.1: hydrogenchloride / methanol; diethyl ether

With N-ethylmorpholine;; hydrogenchloride; sodium hydroxide; water; sodium carbonate; benzotriazol-1-ol; O-phenyl phosphorodichloridate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; diethyl ether; water; N,N-dimethyl-formamide; 4.1: Suzuki Coupling;