(4-(2-bromoethoxy-1,1,2,2-d⁴)-5-((4-methoxybenzyl)oxy)pyridin-2-yl)methyl acetate

Base Information

• Chemical Name: (4-(2-bromoethoxy-1,1,2,2-d⁴)-5-((4-methoxybenzyl)oxy)pyridin-2-yl)methyl acetate
• CAS No.: 1229514-90-2
• Molecular Formula: C₁₈H₂₀BrNO₅
• Molecular Weight: 414.233
• Mol file: 1229514-90-2.mol

Synonyms:(4-(2-bromoethoxy-1,1,2,2-d⁴)-5-((4-methoxybenzyl)oxy)pyridin-2-yl)methyl acetate

Chemical Property of (4-(2-bromoethoxy-1,1,2,2-d⁴)-5-((4-methoxybenzyl)oxy)pyridin-2-yl)methyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(2-bromoethoxy-1,1,2,2-d⁴)-5-((4-methoxybenzyl)oxy)pyridin-2-yl)methyl acetate

There total 2 articles about (4-(2-bromoethoxy-1,1,2,2-d⁴)-5-((4-methoxybenzyl)oxy)pyridin-2-yl)methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

[5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate (724788-77-6) + 1,2-dibromoethane-d4 (22581-63-1) → (4-(2-bromoethoxy-1,1,2,2-d4)-5-((4-methoxybenzyl)oxy)pyridin-2-yl)methyl acetate (1229514-90-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 3h;

Reference yield: 52.0%

1,2-dibromoethane-d4 (22581-63-1) + (4-hydroxy-5-((4-methoxybenzyl)oxy)pyridin-2-yl)methyl acetate (724788-77-6) → (4-(2-bromoethoxy-1,1,2,2-d4)-5-((4-methoxybenzyl)oxy)pyridin-2-yl)methyl acetate (1229514-90-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 2h;

Reference yield:

(4-(2-bromoethoxy-1,1,2,2-d4)-5-((4-methoxybenzyl)oxy)pyridin-2-yl)methyl acetate (1229514-90-2) → N-(3-((2S,5R)-6-amino-2-(fluoromethyl)-5-methyl-5-(methylsulfonyl)-2,3,4,5-tetrahydropyridin-2-yl)-4-fluorophenyl)-2,3-dihydro[1,4]dioxino[2,3-c]pyridine-2,2,3,3-d4-7-carboxamide

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; water / acetic acid / 0 - 60 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 75 °C

3: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite; sodium hypochlorite / acetonitrile; aq. phosphate buffer / 17.5 h / 35 °C / pH 7

4: hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / isopropyl alcohol; methanol / 3.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; aq. phosphate buffer; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

upstream raw materials:

[5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate

1,2-dibromoethane-d4

(4-hydroxy-5-((4-methoxybenzyl)oxy)pyridin-2-yl)methyl acetate