[5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate

Base Information

• Chemical Name: [5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate
• CAS No.: 724788-77-6
• Molecular Formula: C₁₆H₁₇NO₅
• Molecular Weight: 303.315
• Mol file: 724788-77-6.mol

Synonyms:[5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate

Chemical Property of [5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate

There total 2 articles about [5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-(hydroxymethyl)-5-((4-methoxybenzyl)oxy)pyridin-4(1H)-one (118679-90-6) + acetyl chloride (75-36-5) → [5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate (724788-77-6)

Guidance literature:

With pyridine; at 5 - 60 ℃; for 18h;

Reference yield:

[5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate (724788-77-6) → (4-hydroxy-5-((4-methoxybenzyl)oxy)pyridin-2-yl)methyl acetate (724788-77-6)

Guidance literature:

[5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With pyridine; In tetrahydrofuran; at 0 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2010.07.099

Reference yield: 70.0%

[5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate (724788-77-6) + trifluoromethylsulfonic anhydride (358-23-6) → (5-({[4-(methyloxy)phenyl]methyl}oxy)-4-{[(trifluoromethyl)sulfonyl]oxy}-2-pyridinyl)methyl acetate (724788-78-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

2-(hydroxymethyl)-5-((4-methoxybenzyl)oxy)pyridin-4(1H)-one

acetyl chloride

Downstream raw materials:

(5-({[4-(methyloxy)phenyl]methyl}oxy)-4-{[(trifluoromethyl)sulfonyl]oxy}-2-pyridinyl)methyl acetate

{5-({[4-(methyloxy)phenyl]methyl}oxy)-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate

(4-(2-bromoethoxy-1,1,2,2-d⁴)-5-((4-methoxybenzyl)oxy)pyridin-2-yl)methyl acetate

{5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate