methyl (Z)-2-[1-hydroxy-1-(4-nitrophenyl)methyl]-3-methyl-sulfanylacrylate

Base Information

• Chemical Name: methyl (Z)-2-[1-hydroxy-1-(4-nitrophenyl)methyl]-3-methyl-sulfanylacrylate
• CAS No.: 585532-65-6
• Molecular Formula: C₁₂H₁₃NO₅S
• Molecular Weight: 283.305
• Mol file: 585532-65-6.mol

Synonyms:methyl (Z)-2-[1-hydroxy-1-(4-nitrophenyl)methyl]-3-methyl-sulfanylacrylate

Chemical Property of methyl (Z)-2-[1-hydroxy-1-(4-nitrophenyl)methyl]-3-methyl-sulfanylacrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (Z)-2-[1-hydroxy-1-(4-nitrophenyl)methyl]-3-methyl-sulfanylacrylate

There total 2 articles about methyl (Z)-2-[1-hydroxy-1-(4-nitrophenyl)methyl]-3-methyl-sulfanylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methyl (Z)-3-chloro-2-[1-hydroxy-1-(4-nitrophenyl)methyl]acrylate (299160-80-8) + sodium thiomethoxide (5188-07-8) → methyl (Z)-2-[1-hydroxy-1-(4-nitrophenyl)methyl]-3-methyl-sulfanylacrylate (585532-65-6)

Guidance literature:

In methanol; at 20 ℃; for 0.166667h;

DOI:10.1002/chem.200390169

Reference yield:

dimethylsulfide (75-18-3) + 4-nitrobenzaldehdye (555-16-8) + propynoic acid methyl ester (922-67-8) → methyl (E)-3-bromo-2-[1-hydroxy-1-(4-nitrophenyl)methyl]acrylate + methyl (Z)-3-bromo-2-[1-hydroxy-1-(4-nitrophenyl)methyl]acrylate + methyl (E)-2-[1-hydroxy-1-(4-nitrophenyl)methyl]-3-methyl-sulfanylacrylate + methyl (Z)-2-[1-hydroxy-1-(4-nitrophenyl)methyl]-3-methyl-sulfanylacrylate (585532-65-6)

Guidance literature:

With titanium(IV) bromide; In dichloromethane; at -20 ℃; for 60h; Further Variations:; Temperatures; time; Product distribution;

DOI:10.1002/chem.200390169

Reference yield: 85.0%

methyl (Z)-2-[1-hydroxy-1-(4-nitrophenyl)methyl]-3-methyl-sulfanylacrylate (585532-65-6) → methyl (E)-2-formyl-3-(4-nitrophenyl)propenoate (585532-74-7)

Guidance literature:

With trimethoxonium tetrafluoroborate; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/chem.200390169

upstream raw materials:

dimethylsulfide

4-nitrobenzaldehdye

propynoic acid methyl ester

methyl (Z)-3-chloro-2-[1-hydroxy-1-(4-nitrophenyl)methyl]acrylate

Downstream raw materials:

methyl (Z)-3-chloro-2-[1-hydroxy-1-(4-nitrophenyl)methyl]acrylate

methyl (E)-2-formyl-3-(4-nitrophenyl)propenoate