trans-1-α-naphthyl-3-(methylphenylamino)-4-(p-chlorophenyl)-2-azetidinone

Base Information

• Chemical Name: trans-1-α-naphthyl-3-(methylphenylamino)-4-(p-chlorophenyl)-2-azetidinone
• CAS No.: 135569-43-6
• Molecular Formula: C₂₆H₂₁ClN₂O
• Molecular Weight: 412.919
• Mol file: 135569-43-6.mol

Synonyms:trans-1-α-naphthyl-3-(methylphenylamino)-4-(p-chlorophenyl)-2-azetidinone

Chemical Property of trans-1-α-naphthyl-3-(methylphenylamino)-4-(p-chlorophenyl)-2-azetidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-1-α-naphthyl-3-(methylphenylamino)-4-(p-chlorophenyl)-2-azetidinone

There total 3 articles about trans-1-α-naphthyl-3-(methylphenylamino)-4-(p-chlorophenyl)-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(E)-N-(4-chlorobenzylidene) naphthalen-1-amine (135569-53-8) + N-phenyl-N-methylglycine hydrochloride (21911-75-1) → trans-1-α-naphthyl-3-(methylphenylamino)-4-(p-chlorophenyl)-2-azetidinone (135569-43-6)

Guidance literature:

With triethylamine; p-toluenesulfonyl chloride; In benzene; Ambient temperature;

DOI:10.1021/jo00021a029

Reference yield:

1-amino-naphthalene (134-32-7) → trans-1-α-naphthyl-3-(methylphenylamino)-4-(p-chlorophenyl)-2-azetidinone (135569-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Heating

2: 73 percent / p-toluenesulfonyl chloride, Et₃N / benzene / Ambient temperature

With triethylamine; p-toluenesulfonyl chloride; In benzene;

DOI:10.1021/jo00021a029

Reference yield:

4-chlorobenzaldehyde (104-88-1) → trans-1-α-naphthyl-3-(methylphenylamino)-4-(p-chlorophenyl)-2-azetidinone (135569-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Heating

2: 73 percent / p-toluenesulfonyl chloride, Et₃N / benzene / Ambient temperature

With triethylamine; p-toluenesulfonyl chloride; In benzene;

DOI:10.1021/jo00021a029

upstream raw materials:

(E)-N-(4-chlorobenzylidene) naphthalen-1-amine

N-phenyl-N-methylglycine hydrochloride

4-chlorobenzaldehyde

1-amino-naphthalene