21911-75-1Relevant academic research and scientific papers
Iron-catalyzed reductive strecker reaction
Yan, Fachao,Huang, Zijun,Du, Chen-Xia,Bai, Jian-Fei,Li, Yuehui
, p. 188 - 194 (2021/02/03)
Strecker reaction is widely applied for the synthesis of amino acids from aldehydes, amines and cyanides. Herein, we report the FeI2-catalyzed reductive Strecker type reaction of formamides instead of aldehydes to produce amino acetonitriles. The challenging capture of carbinolamine intermediates by CN? was achieved via Fe catalysis. This approach afforded better yields than the use of Ir- or Rh-catalysts. The application ability of this methodology is demonstrated by 1) one-pot construction of (13C labeled) complex molecules from CO2 via amino acetonitrile intermediates and 2) convenient production of homologated carboxylic acids from aldehydes.
Amide derivatives and methods of their use
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Page/Page column 29-30, (2008/06/13)
Amide derivatives of the general formulae Ia and Ib: are disclosed. Pharmaceutical compositions containing these compounds, and methods for their use, inter alia, for treating and/or preventing gastrointestinal disorders, pain, and pruritus are also disclosed.
Cycloadditions of (Arylalkylamino)ketenes with Cycloalkenes
Brady, William T.,Gu, Yi Qi
, p. 2834 - 2838 (2007/10/02)
(Arylalkylamino)ketenes were prepared from the corresponding glycine derivatives and underwent in situ cycloadditions with cyclopentadiene, cycloheptene, and cyclooctene to yield only the endo-bicyclocyclobutanones.The cycloheptene and cyclooctene cycload
