vinyl 9-(3-bromo-4-fluorophenyl)-8-oxo-2,3,5,7,8,9-hexahydrothieno[3,2-b][1,7]naphthyridine-6(4H)-carboxylate 1,1-dioxide

Base Information

Chemical Name:vinyl 9-(3-bromo-4-fluorophenyl)-8-oxo-2,3,5,7,8,9-hexahydrothieno[3,2-b][1,7]naphthyridine-6(4H)-carboxylate 1,1-dioxide
CAS No.:265321-04-8
Molecular Formula:C₁₉H₁₆BrFN₂O₅S
Molecular Weight:483.315
Hs Code.:

Synonyms:vinyl 9-(3-bromo-4-fluorophenyl)-8-oxo-2,3,5,7,8,9-hexahydrothieno[3,2-b][1,7]naphthyridine-6(4H)-carboxylate 1,1-dioxide

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Chemical Property of vinyl 9-(3-bromo-4-fluorophenyl)-8-oxo-2,3,5,7,8,9-hexahydrothieno[3,2-b][1,7]naphthyridine-6(4H)-carboxylate 1,1-dioxide

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Technology Process of vinyl 9-(3-bromo-4-fluorophenyl)-8-oxo-2,3,5,7,8,9-hexahydrothieno[3,2-b][1,7]naphthyridine-6(4H)-carboxylate 1,1-dioxide

There total 3 articles about vinyl 9-(3-bromo-4-fluorophenyl)-8-oxo-2,3,5,7,8,9-hexahydrothieno[3,2-b][1,7]naphthyridine-6(4H)-carboxylate 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5130-24-5
Vinyl chloroformate

: 265321-02-6
6-benzyl-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b][1,7]naphthyridin-8(4H)-one,1,1-dioxide

: 265321-04-8
vinyl 9-(3-bromo-4-fluorophenyl)-8-oxo-2,3,5,7,8,9-hexahydrothieno[3,2-b][1,7]naphthyridine-6(4H)-carboxylate 1,1-dioxide

Guidance literature:: In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jm030357o

Reference yield:

: 50866-56-3
1-(benzyl)piperidin-3,5-dione

: 265321-04-8
vinyl 9-(3-bromo-4-fluorophenyl)-8-oxo-2,3,5,7,8,9-hexahydrothieno[3,2-b][1,7]naphthyridine-6(4H)-carboxylate 1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: NH₃ / ethanol / 4 h

1.2: 0.28 g / ethanol / 48 h / 75 °C

2.1: 0.28 g / CH₂Cl₂ / 24 h / 20 °C

With ammonia; In ethanol; dichloromethane;
DOI:10.1021/jm030357o

Reference yield:

: 77771-02-9
3-bromo-4-fluorobenzaldehyde

: 265321-04-8
vinyl 9-(3-bromo-4-fluorophenyl)-8-oxo-2,3,5,7,8,9-hexahydrothieno[3,2-b][1,7]naphthyridine-6(4H)-carboxylate 1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: NH₃ / ethanol / 4 h

1.2: 0.28 g / ethanol / 48 h / 75 °C

2.1: 0.28 g / CH₂Cl₂ / 24 h / 20 °C

With ammonia; In ethanol; dichloromethane;
DOI:10.1021/jm030357o