50866-56-3

Basic information

• Product Name: 1-benzylpiperidine-3,5-dione
• Synonyms: 3,5-PIPERIDINE, 1-(PHENYLMETHYL)-;1-benzylpiperidine-3,5-dione;1-(Phenylmethyl)-3,5-piperidinedione
• CAS NO: 50866-56-3
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.24
• Product Categories: Heterocyclic Building Blocks
• Mol File: 50866-56-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 87-89 °C(Solv: water (7732-18-5); methanol (67-56-1))
• Boiling Point: 352.726 °C at 760 mmHg
• Flash Point: 159.921 °C
• Appearance: /
• Density: 1.204 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.22±0.20(Predicted)
• CAS DataBase Reference: 1-benzylpiperidine-3,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzylpiperidine-3,5-dione(50866-56-3)
• EPA Substance Registry System: 1-benzylpiperidine-3,5-dione(50866-56-3)

Safety Data

• Hazardous Substances Data: 50866-56-3(Hazardous Substances Data)

Usage

Description

1-Benzylpiperidine-3,5-dione, also known as N-benzylsuccinimide, is a cyclic imide derivative with the molecular formula C15H15NO2. It is a white crystalline solid with a slight odor and is soluble in polar organic solvents. This chemical compound has been studied for its potential applications in medicinal chemistry, particularly for its anticonvulsant and neuroprotective properties. It is also considered a promising building block in the synthesis of various bioactive compounds and a precursor in the development of new drugs.

Uses

Used in Pharmaceutical Industry:
1-Benzylpiperidine-3,5-dione is used as a key intermediate in the synthesis of organic compounds and pharmaceuticals for its potential applications in medicinal chemistry.
Used in Medicinal Chemistry Research:
1-Benzylpiperidine-3,5-dione is used as a research compound for its anticonvulsant and neuroprotective properties, contributing to the development of new treatments for neurological disorders.
Used in Synthesis of Bioactive Compounds:
1-Benzylpiperidine-3,5-dione is used as a building block in the synthesis of various bioactive compounds, enabling the creation of novel therapeutic agents with potential medicinal applications.
Used in Drug Development:
1-Benzylpiperidine-3,5-dione is used as a precursor in the development of new drugs, facilitating the discovery and synthesis of innovative pharmaceuticals to address unmet medical needs.

Upstream product

• 100-46-9 benzylamine 
• 15057-43-9 1-benzyl-3-oxo-5-hydroxy-1,2,3,6-tetrahydropyridine 
• 15057-40-6 ethyl 2-(benzyl(2-oxopropyl)amino)acetate 
• 6436-90-4 ethyl 2-(benzylamino)acetate 

Downstream Products

• 130452-13-0 1-benzyl-3-(o-methoxyanilino)-5-oxo-3,4-dehydropiperidine 
• 74647-10-2 1-Benzyl-3-(o-aminoanilino)-5-oxo-3,4-dehydropiperidine 
• 265320-99-8 7-benzyl-10-(3-bromo-4-fluorophenyl)-3,4,6,7,8,10-hexahydro-2H-thiopyrano[3,2-b][1,7]naphthyridin-9(5H)-one 1,1-dioxide 
• 265320-89-6 2-benzyl-5-(3-bromo-4-fluorophenyl)-2,3,5,8,9,10-hexahydrobenzo[b][1,7]naphthyridine-4,6(1H,7H)-dione 
• 64436-92-6 3-amino-5-methoxypyridine 
• 78156-32-8 3-acetamido-1-benzyl-5-oxo-3,4-dehydropiperidine 
• 78172-06-2 N-(1-Benzyl-4-bromo-5-oxo-1,2,5,6-tetrahydro-pyridin-3-yl)-acetamide 
• 78156-33-9 C₁₄H₁₄N₂O₂ 
• 78156-34-0 C₁₅H₁₆N₂O₂ 
• 345231-58-5 C₁₆H₂₀N₂O₄ 
• 1378014-62-0 2-amino-7-benzyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-pyrano[2,3-c]pyridine-3-carbonitrile 
• 265320-92-1 divinyl 5-(3-bromo-4-fluorophenyl)-4,6-dioxo-4,5,6,7,9,10-hexahydropyrido[3,4-b][1,7]naphthyridine-2,8(1H,3H)-dicarboxylate 
• 265321-00-4 vinyl 10-(3-bromo-4-fluorophenyl)-9-oxo-3,4,6,8,9,10-hexahydro-2H-thiopyrano[3,2-b][1,7]naphthyridin-7(5H)-carboxylate 1,1-dioxide 
• 265321-21-9 Vinyl 5-(3-bromo-4-fluorophenyl)-4,6-dioxo-4,5,6,7,9,10-hexahydro-1H-pyrano[3,4-b][1,7]naphthyridine-8(3H)-carboxylate 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS

The invention relates to a compound of formula (I) and a racemate, an enantiomer, a diastereoisomer, a geometric isomer or a pharmaceutically acceptable salt thereof, and its use as antibacterial agent.

ANTIMICROBIAL COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT OF INFECTIONS

The present disclosure provides compositions including a compound (e.g., compounds A-D), pharmaceutical compositions including the compound, methods of treatment of a condition (e.g., an infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

Divergent asymmetric synthesis of 3,5-disubstituted piperidines

A divergent synthesis of various 3,5-dioxygenated piperidines with interesting pharmacological properties is described. A mixture of the achiral cis- and racemic trans-3,5-piperidine diol could be efficiently obtained from N-benzylglycinate in five steps