50866-56-3

Basic information

• Product Name: 1-benzylpiperidine-3,5-dione
• Synonyms: 3,5-PIPERIDINE, 1-(PHENYLMETHYL)-;1-benzylpiperidine-3,5-dione;1-(Phenylmethyl)-3,5-piperidinedione
• CAS NO: 50866-56-3
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.24
• Product Categories: Heterocyclic Building Blocks
• Mol File: 50866-56-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 87-89 °C(Solv: water (7732-18-5); methanol (67-56-1))
• Boiling Point: 352.726 °C at 760 mmHg
• Flash Point: 159.921 °C
• Appearance: /
• Density: 1.204 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.22±0.20(Predicted)
• CAS DataBase Reference: 1-benzylpiperidine-3,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzylpiperidine-3,5-dione(50866-56-3)
• EPA Substance Registry System: 1-benzylpiperidine-3,5-dione(50866-56-3)

Safety Data

• Hazardous Substances Data: 50866-56-3(Hazardous Substances Data)

Usage

General Description

1-Benzylpiperidine-3,5-dione, also known as N-benzylsuccinimide, is a chemical compound with the molecular formula C15H15NO2. It is a cyclic imide derivative, typically used in the synthesis of organic compounds and pharmaceuticals. It is a white crystalline solid with a slight odor, and it is soluble in polar organic solvents. 1-Benzylpiperidine-3,5-dione has been studied for its potential applications in the field of medicinal chemistry, particularly for its anticonvulsant and neuroprotective properties. Additionally, it has been investigated for its potential use as a building block in the synthesis of various bioactive compounds and as a precursor in the development of new drugs.

Upstream product

• 100-46-9 benzylamine 
• 15057-43-9 1-benzyl-3-oxo-5-hydroxy-1,2,3,6-tetrahydropyridine 
• 15057-40-6 ethyl 2-(benzyl(2-oxopropyl)amino)acetate 
• 6436-90-4 ethyl 2-(benzylamino)acetate 

Downstream Products

• 74647-10-2 1-Benzyl-3-(o-aminoanilino)-5-oxo-3,4-dehydropiperidine 
• 265321-19-5 8-benzyl-5-(3-bromo-4-fluorophenyl)-5,8,9,10-tetrahydro-1H-pyrano[3,4-b][1,7]naphthyridine-4,6(3H,7H)-dione 
• 130452-19-6 2-benzyl-4-oxo-5-methoxy-1,2,3,4-tetrahydro-β-carboline 
• 130452-17-4 2-benzyl-4-oxo-8-methoxy-1,2,3,4-tetrahydro-β-carboline 
• 130452-18-5 2-benzyl-4-oxo-6-methoxy-1,2,3,4-tetrahydro-β-carboline 
• 130452-20-9 2-benzyl-4-oxo-7-methoxy-1,2,3,4-tetrahydro-β-carboline 
• 265321-31-1 methyl 7-benzyl-4-(3-bromo-4-fluorophenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro[1,7]naphthyridine-3-carboxylate 
• 1378014-62-0 2-amino-7-benzyl-5-oxo-4-phenyl-5,6,7,8-tetrahydro-4H-pyrano[2,3-c]pyridine-3-carbonitrile 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS

The invention relates to a compound of formula (I) and a racemate, an enantiomer, a diastereoisomer, a geometric isomer or a pharmaceutically acceptable salt thereof, and its use as antibacterial agent.

ANTIMICROBIAL COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT OF INFECTIONS

The present disclosure provides compositions including a compound (e.g., compounds A-D), pharmaceutical compositions including the compound, methods of treatment of a condition (e.g., an infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

Divergent asymmetric synthesis of 3,5-disubstituted piperidines

A divergent synthesis of various 3,5-dioxygenated piperidines with interesting pharmacological properties is described. A mixture of the achiral cis- and racemic trans-3,5-piperidine diol could be efficiently obtained from N-benzylglycinate in five steps