N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid methyl ester

Base Information

Chemical Name:N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid methyl ester
CAS No.:83948-72-5
Molecular Formula:C₃₁H₄₂N₄O₉
Molecular Weight:614.696
Hs Code.:

Synonyms:N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid methyl ester

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Chemical Property of N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid methyl ester

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Technology Process of N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid methyl ester

There total 12 articles about N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 83948-72-5
N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / NEt₃ / tetrahydrofuran; H₂O / 2 h / Ambient temperature

2: 41 percent / PPh₃, diisopropyl azodicarboxylate / tetrahydrofuran / 1.5 h / Ambient temperature

3: 81.7 percent / dioxane; H₂O / 50 °C

4: 1.) Et₃N / 1.) MeCN, room temperature, 1 h, 2.) 2-3 h room temperature

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jo00149a005

Reference yield:

: 83948-52-1
O-Benzyl-N-(p-nitrobenzyloxycarbonyl)hydroxylamine

: 83948-72-5
N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / PPh₃, DEAD / tetrahydrofuran / 1.5 h / Ambient temperature

2: 55 percent / H₂ / 5percent Pd/C / ethyl acetate / 3 h / 0 °C / 760 Torr

3: 97 percent / HCl gas / diethyl ether / 0 °C

4: Et₃N / acetonitrile / 3.5 h / Ambient temperature

5: 75 percent / dioxane; H₂O / 168 h

6: 1.) Et₃N / 1.) MeCN, room temperature, 1 h, 2.) 2-3 h room temperature

With hydrogenchloride; hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; ethyl acetate; acetonitrile;
DOI:10.1021/jo00149a005

Reference yield:

: 15255-86-4
N-benzyloxycarbonyl-O-benzylhydroxylamine

: 83948-72-5
N-[3-(Acetyl-benzyloxy-amino)-propyl]-2-{[3-(acetyl-benzyloxy-amino)-propylcarbamoyl]-methyl}-2-hydroxy-succinamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / PPh₃, DEAD / tetrahydrofuran / 1.5 h / Ambient temperature

2: 65 percent / H₂ / 5percent Pd/C / ethyl acetate / 3 h / 0 °C / 760 Torr

3: 97 percent / HCl gas / diethyl ether / 0 °C

4: Et₃N / acetonitrile / 3.5 h / Ambient temperature

5: 75 percent / dioxane; H₂O / 168 h

6: 1.) Et₃N / 1.) MeCN, room temperature, 1 h, 2.) 2-3 h room temperature

With hydrogenchloride; hydrogen; triethylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; ethyl acetate; acetonitrile;
DOI:10.1021/jo00149a005