Cbz-L-Ala-D-Gln

Base Information

• Chemical Name: Cbz-L-Ala-D-Gln
• CAS No.: 74842-54-9
• Molecular Formula: C₁₆H₂₁N₃O₆
• Molecular Weight: 351.359
• Mol file: 74842-54-9.mol

Synonyms:Cbz-L-Ala-D-Gln

Chemical Property of Cbz-L-Ala-D-Gln

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbz-L-Ala-D-Gln

There total 1 articles about Cbz-L-Ala-D-Gln which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-Glutamin (5959-95-5,26700-71-0) + (N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester (3401-36-3) → Cbz-L-Ala-D-Gln (74842-54-9)

Guidance literature:

With triethylamine; 1-amino-3-(dimethylamino)propane; Yield given. Multistep reaction; 1.) THF, H₂O, 4 deg C, 24 h, 2.) THF, H₂O, 1 h;

DOI:10.1021/jm00343a018

Reference yield: 69.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + Cbz-L-Ala-D-Gln (74842-54-9) → Cbz-L-Ala-D-Gln-OCH3 (79787-32-9)

Guidance literature:

In tetrahydrofuran; methanol; diethyl ether; for 0.166667h; Ambient temperature;

DOI:10.1021/jm00343a018

Reference yield:

Cbz-L-Ala-D-Gln (74842-54-9) → 1-α-O-benzyl-4,6-O-benzylidene-N-acetylmuramyl-L-alanyl-D-glutamine methyl ester (74835-96-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / methanol; tetrahydrofuran; diethyl ether / 0.17 h / Ambient temperature

2: H₂, HOAc, 1 N HCl / 5percent Pd/C / 2 h / 760 Torr

3: N-methylmorpholine, isobutyl chloroformate / dimethylformamide / -15 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; acetic acid; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/jm00343a018

upstream raw materials:

D-Glutamin

(N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester

Downstream raw materials:

Cbz-L-Ala-D-Gln-OCH₃

Cbz-L-Ala-D-Gln-O-n-C₄H₉

Cbz-L-Ala-D-Gln-O-n-C₅H₁₁

Cbz-L-Ala-D-Gln-O-n-C₆H₁₃