N-[(5-(benzyloxy)-4-oxo-4H-pyran-2-yl)(cyclohexylcarbamoyl)methyl]-N-(4-chlorophenyl)benzamide

Base Information

Chemical Name:N-[(5-(benzyloxy)-4-oxo-4H-pyran-2-yl)(cyclohexylcarbamoyl)methyl]-N-(4-chlorophenyl)benzamide
CAS No.:1449029-98-4
Molecular Formula:C₃₃H₃₁ClN₂O₅
Molecular Weight:571.073
Hs Code.:

Synonyms:N-[(5-(benzyloxy)-4-oxo-4H-pyran-2-yl)(cyclohexylcarbamoyl)methyl]-N-(4-chlorophenyl)benzamide

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Chemical Property of N-[(5-(benzyloxy)-4-oxo-4H-pyran-2-yl)(cyclohexylcarbamoyl)methyl]-N-(4-chlorophenyl)benzamide

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Technology Process of N-[(5-(benzyloxy)-4-oxo-4H-pyran-2-yl)(cyclohexylcarbamoyl)methyl]-N-(4-chlorophenyl)benzamide

There total 4 articles about N-[(5-(benzyloxy)-4-oxo-4H-pyran-2-yl)(cyclohexylcarbamoyl)methyl]-N-(4-chlorophenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 18234-41-8
5-(benzyloxy)-4-oxo-4H-pyran-2-carbaldehyde

: 931-53-3
Cyclohexyl isocyanide

: 106-47-8
4-chloro-aniline

: 65-85-0,8013-63-6
benzoic acid

: 1449029-98-4
N-[(5-(benzyloxy)-4-oxo-4H-pyran-2-yl)(cyclohexylcarbamoyl)methyl]-N-(4-chlorophenyl)benzamide

Guidance literature:: 5-(benzyloxy)-4-oxo-4H-pyran-2-carbaldehyde; 4-chloro-aniline; In methanol; at 20 ℃; for 0.5h;

Cyclohexyl isocyanide; benzoic acid; In methanol; at 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2013.05.049

Reference yield:

: 501-30-4,123712-78-7
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

: 1449029-98-4
N-[(5-(benzyloxy)-4-oxo-4H-pyran-2-yl)(cyclohexylcarbamoyl)methyl]-N-(4-chlorophenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol; water / 4 h / 60 °C

2.1: manganese(IV) oxide / dichloromethane / 72 h / 20 °C

3.1: methanol / 0.5 h / 20 °C

3.2: 24 h / 20 °C

With manganese(IV) oxide; sodium hydroxide; In methanol; dichloromethane; water; 3.1: |Ugi Condensation / 3.2: |Ugi Condensation;
DOI:10.1016/j.ejmech.2013.05.049

Reference yield:

: 15771-06-9
5-benzyloxy-2-hydroxymethyl-4H-pyran-4-one

: 1449029-98-4
N-[(5-(benzyloxy)-4-oxo-4H-pyran-2-yl)(cyclohexylcarbamoyl)methyl]-N-(4-chlorophenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: manganese(IV) oxide / dichloromethane / 72 h / 20 °C

2.1: methanol / 0.5 h / 20 °C

2.2: 24 h / 20 °C

With manganese(IV) oxide; In methanol; dichloromethane; 2.1: |Ugi Condensation / 2.2: |Ugi Condensation;
DOI:10.1016/j.ejmech.2013.05.049