ethyl 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>1-methylpyrazole-5-carboxylate

Base Information

Chemical Name:ethyl 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>1-methylpyrazole-5-carboxylate
CAS No.:161463-32-7
Molecular Formula:C₂₅H₂₇N₃O₂
Molecular Weight:401.508
Hs Code.:

Synonyms:ethyl 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>1-methylpyrazole-5-carboxylate

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Chemical Property of ethyl 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>1-methylpyrazole-5-carboxylate

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Technology Process of ethyl 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>1-methylpyrazole-5-carboxylate

There total 8 articles about ethyl 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>1-methylpyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 64-17-5
ethanol

: 161463-31-6
3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>-1-methylpyrazole-5-carboxylic acid

: 161463-32-7
ethyl 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>1-methylpyrazole-5-carboxylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In chloroform; for 2h; Ambient temperature;
DOI:10.1248/cpb.42.1617

Reference yield:

: 591-78-6
n-hexan-2-one

: 161463-32-7
ethyl 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>1-methylpyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 56 percent / Na / toluene / 2 h / 55 °C

2: 64 percent / N,N-diisopropylethylamine, LiBr / tetrahydrofuran / 15 h / Heating

3: hydrazine hydrate / ethanol / 2 h / Heating

4: DBU / acetone / 8 h / 45 °C

5: BBr₃ / CH₂Cl₂ / 13 h / 0 - 20 °C

6: Na₂CO₃, H₂O / dioxane / 3 h / Heating

7: 32 percent / Na₂Cr₂O₇*2H₂O, H₂O, H₂SO₄ / 5 h / 35 °C

8: 77 percent / DCC, DMAP / CHCl₃ / 2 h / Ambient temperature

With dmap; sodium dichromate; sulfuric acid; water; sodium; boron tribromide; sodium carbonate; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; lithium bromide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; acetone; toluene;
DOI:10.1248/cpb.42.1617

Reference yield:

: 124806-74-2
1-Methoxy-2,4-octandione

: 161463-32-7
ethyl 3-n-butyl-4-<(2'-cyanobiphenyl-4-yl)methyl>1-methylpyrazole-5-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 64 percent / N,N-diisopropylethylamine, LiBr / tetrahydrofuran / 15 h / Heating

2: hydrazine hydrate / ethanol / 2 h / Heating

3: DBU / acetone / 8 h / 45 °C

4: BBr₃ / CH₂Cl₂ / 13 h / 0 - 20 °C

5: Na₂CO₃, H₂O / dioxane / 3 h / Heating

6: 32 percent / Na₂Cr₂O₇*2H₂O, H₂O, H₂SO₄ / 5 h / 35 °C

7: 77 percent / DCC, DMAP / CHCl₃ / 2 h / Ambient temperature

With dmap; sodium dichromate; sulfuric acid; water; boron tribromide; sodium carbonate; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; lithium bromide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; acetone;
DOI:10.1248/cpb.42.1617