2-(2,2-difluoroethoxy)-4-((4-(difluoromethoxy)-3-methylphenyl)ethynyl)-1-fluorobenzene

Base Information

Chemical Name:2-(2,2-difluoroethoxy)-4-((4-(difluoromethoxy)-3-methylphenyl)ethynyl)-1-fluorobenzene
CAS No.:1062614-72-5
Molecular Formula:C₁₈H₁₃F₅O₂
Molecular Weight:356.292
Hs Code.:

Synonyms:2-(2,2-difluoroethoxy)-4-((4-(difluoromethoxy)-3-methylphenyl)ethynyl)-1-fluorobenzene

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Chemical Property of 2-(2,2-difluoroethoxy)-4-((4-(difluoromethoxy)-3-methylphenyl)ethynyl)-1-fluorobenzene

Chemical Property:

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Technology Process of 2-(2,2-difluoroethoxy)-4-((4-(difluoromethoxy)-3-methylphenyl)ethynyl)-1-fluorobenzene

There total 8 articles about 2-(2,2-difluoroethoxy)-4-((4-(difluoromethoxy)-3-methylphenyl)ethynyl)-1-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1062613-75-5
1-(difluoromethoxy)-4-ethynyl-2-methylbenzene

: 1062616-16-3
4-bromo-1-(difluoromethoxy)-2-(2-methoxyethyl)benzene

: 1062614-72-5
2-(2,2-difluoroethoxy)-4-((4-(difluoromethoxy)-3-methylphenyl)ethynyl)-1-fluorobenzene

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 70 ℃; Product distribution / selectivity;

Reference yield:

: 888327-32-0
4-bromo-1-(difluoromethoxy)-2-methylbenzene

: 1062614-72-5
2-(2,2-difluoroethoxy)-4-((4-(difluoromethoxy)-3-methylphenyl)ethynyl)-1-fluorobenzene

Guidance literature:: Multi-step reaction with 3 steps

1: pyrrolidine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 4 h / 65 °C

2: methanol; potassium carbonate / 3 h / 20 °C

3: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 6 h / 70 °C

With pyrrolidine; methanol; copper(l) iodide; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1062613-73-3
((4-(difluoromethoxy)-3-methylphenyl)ethynyl)trimethylsilane

: 1062614-72-5
2-(2,2-difluoroethoxy)-4-((4-(difluoromethoxy)-3-methylphenyl)ethynyl)-1-fluorobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; potassium carbonate / 3 h / 20 °C

2: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 6 h / 70 °C

With methanol; copper(l) iodide; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide;