2-(8-oxy-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl)-cyclohexane-1,3-dione

Base Information

Chemical Name:2-(8-oxy-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl)-cyclohexane-1,3-dione
CAS No.:1188432-10-1
Molecular Formula:C₁₆H₁₁F₃N₂O₄
Molecular Weight:352.27
Hs Code.:

Synonyms:2-(8-oxy-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl)-cyclohexane-1,3-dione

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Chemical Property of 2-(8-oxy-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl)-cyclohexane-1,3-dione

Chemical Property:

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Technology Process of 2-(8-oxy-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl)-cyclohexane-1,3-dione

There total 5 articles about 2-(8-oxy-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl)-cyclohexane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1188430-60-5
2-(2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl)-cyclohexane-1,3-dione

: 1188432-10-1
2-(8-oxy-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl)-cyclohexane-1,3-dione

Guidance literature:: With urea hydrogen peroxide adduct; trifluoroacetic anhydride; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 7521-41-7
2-Aminonicotinaldehyde

: 1188432-10-1
2-(8-oxy-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl)-cyclohexane-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: piperidine / ethanol / 2 h / Reflux

2.1: water; sodium hydroxide / ethanol / 6 h / 20 °C

3.1: dicyclohexyl-carbodiimide / acetonitrile / 6 h / 20 °C

3.2: 16 h / 20 °C

4.1: hydrogenchloride / dichloromethane; water

5.1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 20 h / 20 °C

With piperidine; hydrogenchloride; water; urea hydrogen peroxide adduct; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; sodium hydroxide; In ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 241154-08-5
2-trifluoromethyl-[1,8]-naphthyridine-3-carboxylic acid

: 1188432-10-1
2-(8-oxy-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl)-cyclohexane-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide / acetonitrile / 6 h / 20 °C

1.2: 16 h / 20 °C

2.1: hydrogenchloride / dichloromethane; water

3.1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / dichloromethane / 20 h / 20 °C

With hydrogenchloride; urea hydrogen peroxide adduct; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; In dichloromethane; water; acetonitrile;