7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine 4-oxide

Base Information

• Chemical Name: 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine 4-oxide
• CAS No.: 109774-03-0
• Molecular Formula: C₂₁H₁₅ClFN₃O
• Molecular Weight: 379.821

Synonyms:7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine 4-oxide

Chemical Property of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine 4-oxide

Chemical Property:

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Technology Process of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine 4-oxide

There total 1 articles about 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine 4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-picoline (109-06-8) + 6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide (60656-74-8) → 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine 4-oxide (109774-03-0)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1) -50 deg C, tetrahydrofuran 2) warming, 45 min.;

DOI:10.1002/jhet.5570230509

Reference yield: 79.0%

7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine 4-oxide (109774-03-0) → 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine (109774-08-5)

Guidance literature:

With phosphorus trichloride; In tetrahydrofuran; dichloromethane; for 0.25h; Ambient temperature;

DOI:10.1002/jhet.5570230509

Reference yield: 67.0%

7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine 4-oxide (109774-03-0) → <7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-yl>-2-pyridylmethanone oxime 4-oxide (109774-12-1)

Guidance literature:

With acetic acid; sodium nitrite; for 1h;

DOI:10.1002/jhet.5570230509

upstream raw materials:

α-picoline

6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide

Downstream raw materials:

7-chloro-5-(2-fluorophenyl)-2,3-dihydro-2-<(2-pyridyl)methylene>-1H-1,4-benzodiazepine

<7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-yl>-2-pyridylmethanone oxime 4-oxide

8-chloro-6-(2-fluorophenyl)-3-(2-pyridyl)-4H-imidazo<1,5a><1,4>benzodiazepine

<7-chloro-5-(2-fluorophenyl)-3H-1,4-benzodiazepine-2-yl>-2-pyridylmethanone oxime

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