(+/-)-methyl 4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}ethyl)thio]methyl}phenylacetate

Base Information

• Chemical Name: (+/-)-methyl 4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}ethyl)thio]methyl}phenylacetate
• CAS No.: 904916-33-2
• Molecular Formula: C₃₅H₃₀Cl₂N₂O₄S₂
• Molecular Weight: 677.672
• Mol file: 904916-33-2.mol

Synonyms:(+/-)-methyl 4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}ethyl)thio]methyl}phenylacetate

Chemical Property of (+/-)-methyl 4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}ethyl)thio]methyl}phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-methyl 4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}ethyl)thio]methyl}phenylacetate

There total 12 articles about (+/-)-methyl 4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}ethyl)thio]methyl}phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[4-(2-Amino-1-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-ethylsulfanylmethyl)-phenyl]-acetic acid methyl ester + 4-chlorobenzenesulfonyl chloride (98-60-2) → (+/-)-methyl 4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}ethyl)thio]methyl}phenylacetate (904916-33-2)

Guidance literature:

With triethylamine; In 1,2-dichloro-ethane; at 5 ℃; for 12h;

DOI:10.1248/cpb.54.603

Reference yield:

methyl 4-mercaptomethylphenylacetate (149280-86-4) → (+/-)-methyl 4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}ethyl)thio]methyl}phenylacetate (904916-33-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 34 percent / cesium carbonate / dimethylsulfoxide / 1 h / 20 °C

2: methylhydrazine / ethanol; dioxane / 7 h / Heating

3: triethylamine / 1,2-dichloro-ethane / 12 h / 5 °C

With caesium carbonate; triethylamine; methylhydrazine; In 1,4-dioxane; ethanol; dimethyl sulfoxide; 1,2-dichloro-ethane;

DOI:10.1248/cpb.54.603

Reference yield:

(+/-)-2-amino-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}ethanol (203940-21-0) → (+/-)-methyl 4-{[(2-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}ethyl)thio]methyl}phenylacetate (904916-33-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 18.8 g / toluene / 3 h / 160 °C / 3 Torr

2: 19.0 g / pyridine / 1,2-dichloro-ethane / 12 h / 20 °C

3: 34 percent / cesium carbonate / dimethylsulfoxide / 1 h / 20 °C

4: methylhydrazine / ethanol; dioxane / 7 h / Heating

5: triethylamine / 1,2-dichloro-ethane / 12 h / 5 °C

With pyridine; caesium carbonate; triethylamine; methylhydrazine; In 1,4-dioxane; ethanol; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;

DOI:10.1248/cpb.54.603

upstream raw materials:

4-chlorobenzenesulfonyl chloride

methyl 4-mercaptomethylphenylacetate

methyl 3-[(E)-2-(7-chloro-2-quinolyl)vinyl]benzoate

(+/-)-2-amino-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}ethanol