2-(2-(3-(4-((S)-2,3-dihydroxypropoxy)-3,5-dimethylphenyl)-1,2,4-oxadiazol-5-yl)ethyl)-2-(4-fluorophenyl)cyclohexanone

Base Information

Chemical Name:2-(2-(3-(4-((S)-2,3-dihydroxypropoxy)-3,5-dimethylphenyl)-1,2,4-oxadiazol-5-yl)ethyl)-2-(4-fluorophenyl)cyclohexanone
CAS No.:1356464-91-9
Molecular Formula:C₂₇H₃₁FN₂O₅
Molecular Weight:482.552
Hs Code.:

Synonyms:2-(2-(3-(4-((S)-2,3-dihydroxypropoxy)-3,5-dimethylphenyl)-1,2,4-oxadiazol-5-yl)ethyl)-2-(4-fluorophenyl)cyclohexanone

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Chemical Property of 2-(2-(3-(4-((S)-2,3-dihydroxypropoxy)-3,5-dimethylphenyl)-1,2,4-oxadiazol-5-yl)ethyl)-2-(4-fluorophenyl)cyclohexanone

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Technology Process of 2-(2-(3-(4-((S)-2,3-dihydroxypropoxy)-3,5-dimethylphenyl)-1,2,4-oxadiazol-5-yl)ethyl)-2-(4-fluorophenyl)cyclohexanone

There total 3 articles about 2-(2-(3-(4-((S)-2,3-dihydroxypropoxy)-3,5-dimethylphenyl)-1,2,4-oxadiazol-5-yl)ethyl)-2-(4-fluorophenyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1150644-84-0,1356606-31-9
(R)-4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-N-hydroxy-3,5-dimethylbenzimidamide

: 1356464-92-0
3-(1-(4-fluorophenyl)-2-oxocyclohexyl)propanoic acid

: 1356464-91-9
2-(2-(3-(4-((S)-2,3-dihydroxypropoxy)-3,5-dimethylphenyl)-1,2,4-oxadiazol-5-yl)ethyl)-2-(4-fluorophenyl)cyclohexanone

Guidance literature:: (R)-4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-N-hydroxy-3,5-dimethylbenzimidamide; 3-(1-(4-fluorophenyl)-2-oxocyclohexyl)propanoic acid; With diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 1.5h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; acetonitrile; for 18.5h;

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetonitrile; at 0 ℃; for 0.933333h;

Reference yield:

: 4198-90-7
3,5-dimethyl-4-hydroxybenzonitrile

: 1356464-91-9
2-(2-(3-(4-((S)-2,3-dihydroxypropoxy)-3,5-dimethylphenyl)-1,2,4-oxadiazol-5-yl)ethyl)-2-(4-fluorophenyl)cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere; Reflux

1.2: 3.16 h / 65 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride / methanol / 0.17 h / 20 °C / Reflux

2.2: 25.16 h / 60 °C / Inert atmosphere

3.1: diisopropyl-carbodiimide / dichloromethane / 1.5 h / 20 °C

3.2: 18.5 h

3.3: 0.93 h / 0 °C

With hydroxylamine hydrochloride; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1356464-85-1
(R)-4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3,5-dimethylbenzonitrile

: 1356464-91-9
2-(2-(3-(4-((S)-2,3-dihydroxypropoxy)-3,5-dimethylphenyl)-1,2,4-oxadiazol-5-yl)ethyl)-2-(4-fluorophenyl)cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride / methanol / 0.17 h / 20 °C / Reflux

1.2: 25.16 h / 60 °C / Inert atmosphere

2.1: diisopropyl-carbodiimide / dichloromethane / 1.5 h / 20 °C

2.2: 18.5 h

2.3: 0.93 h / 0 °C

With hydroxylamine hydrochloride; diisopropyl-carbodiimide; In methanol; dichloromethane;