C₃₇H₄₅FN₂O₅

Base Information

Chemical Name:C₃₇H₄₅FN₂O₅
CAS No.:950524-34-2
Molecular Formula:C₃₇H₄₅FN₂O₅
Molecular Weight:616.773
Hs Code.:

C<sub>37</sub>H<sub>45</sub>FN<sub>2</sub>O<sub>5</sub>

Synonyms:C₃₇H₄₅FN₂O₅

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Chemical Property of C₃₇H₄₅FN₂O₅

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Technology Process of C₃₇H₄₅FN₂O₅

There total 12 articles about C₃₇H₄₅FN₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: C₄₂H₃₉FN₂OP⁽¹⁺⁾*Br^(1-)

: 124752-23-4
tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate

: 950524-34-2
C₃₇H₄₅FN₂O₅

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 - 25 ℃; for 1h;
DOI:10.1016/j.bmcl.2007.05.097

Reference yield:

: 950524-24-0
C₁₂H₁₂FNO₂

: 950524-34-2
C₃₇H₄₅FN₂O₅

Guidance literature:: Multi-step reaction with 9 steps

1: 92 percent / DBU / tetrahydrofuran / 18 h / 25 °C

2: 75 percent / KOH / dimethylsulfoxide / 2 h / 25 °C

3: 52 percent / NaIO₄; OsO₄ / tetrahydrofuran; H₂O / 18 h / 0 - 25 °C

4: 79 percent / Na(OAc)3BH; AcOH / 1,2-dichloro-ethane / 18 h / 25 °C

5: 94 percent / trimethylaluminum; triethylamine / CH₂Cl₂; toluene / 16 h / 60 °C

6: 97 percent / POCl₃ / 1,2-dichloro-ethane / 18 h / 80 °C

7: 56 percent / LiAl(O-t-Bu)3H / tetrahydrofuran / 0.5 h / 0 °C

8: 100 percent / CH₂Cl₂ / 2 h / 50 °C

9: 85 percent / NHMDS / tetrahydrofuran / 1 h / -78 - 25 °C

With potassium hydroxide; sodium periodate; osmium(VIII) oxide; trimethylaluminum; sodium hexamethyldisilazane; sodium tris(acetoxy)borohydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium tri-t-butoxyaluminum hydride; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; 6: Vilsmeier-Haack formylation / 9: Wittig olefination;
DOI:10.1016/j.bmcl.2007.05.097

Reference yield:

: 950524-22-8
C₁₂H₁₄FNO₃

: 950524-34-2
C₃₇H₄₅FN₂O₅

Guidance literature:: Multi-step reaction with 10 steps

1: 84 percent / trifluoroacetic anhydride; triethylamine / CH₂Cl₂ / 0.5 h / -10 °C

2: 92 percent / DBU / tetrahydrofuran / 18 h / 25 °C

3: 75 percent / KOH / dimethylsulfoxide / 2 h / 25 °C

4: 52 percent / NaIO₄; OsO₄ / tetrahydrofuran; H₂O / 18 h / 0 - 25 °C

5: 79 percent / Na(OAc)3BH; AcOH / 1,2-dichloro-ethane / 18 h / 25 °C

6: 94 percent / trimethylaluminum; triethylamine / CH₂Cl₂; toluene / 16 h / 60 °C

7: 97 percent / POCl₃ / 1,2-dichloro-ethane / 18 h / 80 °C

8: 56 percent / LiAl(O-t-Bu)3H / tetrahydrofuran / 0.5 h / 0 °C

9: 100 percent / CH₂Cl₂ / 2 h / 50 °C

10: 85 percent / NHMDS / tetrahydrofuran / 1 h / -78 - 25 °C

With potassium hydroxide; sodium periodate; osmium(VIII) oxide; trimethylaluminum; sodium hexamethyldisilazane; sodium tris(acetoxy)borohydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium tri-t-butoxyaluminum hydride; triethylamine; trifluoroacetic anhydride; trichlorophosphate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; 7: Vilsmeier-Haack formylation / 10: Wittig olefination;
DOI:10.1016/j.bmcl.2007.05.097