Technology Process of 5-methyl-1-phenyl-1-heptyne
There total 2 articles about 5-methyl-1-phenyl-1-heptyne which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
phenylacetylene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 0.5h;
Inert atmosphere;
Sealed tube;
(R/S)-3-methylpentyl p-toluenesulfonate;
With
N,N,N,N,N,N-hexamethylphosphoric triamide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 2h;
Inert atmosphere;
Sealed tube;
DOI:10.1021/ol501655g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine / 5 h / 0 °C / Inert atmosphere; Sealed tube
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - 20 °C / Inert atmosphere; Sealed tube
2.2: 2 h / -78 - 20 °C / Inert atmosphere; Sealed tube
With
pyridine; n-butyllithium;
In
tetrahydrofuran; hexane;
DOI:10.1021/ol501655g
- Guidance literature:
-
diphenyliodonium hexafluorophosphate;
With
copper(II) bis(trifluoromethanesulfonate);
at 80 ℃;
for 1h;
Inert atmosphere;
Sealed tube;
Schlenk technique;
5-methyl-1-phenyl-1-heptyne;
In
1,2-dichloro-ethane;
at 60 ℃;
for 12h;
regioselective reaction;
Inert atmosphere;
Sealed tube;
Schlenk technique;
DOI:10.1021/ol501655g
