(1'R,3'R)-N-benzyl-8'-isopropoxy-1',3'-dimethyl-1',2',3',4'-tetrahydroisoquinolin-6'-yl 2-bromo-5-isopropoxy-1-benzoate

Base Information

• Chemical Name: (1'R,3'R)-N-benzyl-8'-isopropoxy-1',3'-dimethyl-1',2',3',4'-tetrahydroisoquinolin-6'-yl 2-bromo-5-isopropoxy-1-benzoate
• CAS No.: 218932-20-8
• Molecular Formula: C₃₁H₃₆BrNO₄
• Molecular Weight: 566.535
• Mol file: 218932-20-8.mol

Synonyms:(1'R,3'R)-N-benzyl-8'-isopropoxy-1',3'-dimethyl-1',2',3',4'-tetrahydroisoquinolin-6'-yl 2-bromo-5-isopropoxy-1-benzoate

Chemical Property of (1'R,3'R)-N-benzyl-8'-isopropoxy-1',3'-dimethyl-1',2',3',4'-tetrahydroisoquinolin-6'-yl 2-bromo-5-isopropoxy-1-benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'R,3'R)-N-benzyl-8'-isopropoxy-1',3'-dimethyl-1',2',3',4'-tetrahydroisoquinolin-6'-yl 2-bromo-5-isopropoxy-1-benzoate

There total 3 articles about (1'R,3'R)-N-benzyl-8'-isopropoxy-1',3'-dimethyl-1',2',3',4'-tetrahydroisoquinolin-6'-yl 2-bromo-5-isopropoxy-1-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-Bromo-5-isopropoxy-benzoic acid + (1R,3R)-N-benzyl-6-hydroxy-8-isopropoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline (218956-26-4) → (1'R,3'R)-N-benzyl-8'-isopropoxy-1',3'-dimethyl-1',2',3',4'-tetrahydroisoquinolin-6'-yl 2-bromo-5-isopropoxy-1-benzoate (218932-20-8)

Guidance literature:

2-Bromo-5-isopropoxy-benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 4h;

(1R,3R)-N-benzyl-6-hydroxy-8-isopropoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline; With triethylamine; In dichloromethane; for 5h; Further stages.;

DOI:10.1021/jo991634v

Reference yield:

2-Bromo-5-isopropoxy-benzoic acid → (1'R,3'R)-N-benzyl-8'-isopropoxy-1',3'-dimethyl-1',2',3',4'-tetrahydroisoquinolin-6'-yl 2-bromo-5-isopropoxy-1-benzoate (218932-20-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2, DMF

2: Et₃N

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide;

DOI:10.1055/s-1998-1912

Reference yield:

2-Bromo-5-isopropoxy-benzoyl chloride + (1R,3R)-N-benzyl-6-hydroxy-8-isopropoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline (218956-26-4) → (1'R,3'R)-N-benzyl-8'-isopropoxy-1',3'-dimethyl-1',2',3',4'-tetrahydroisoquinolin-6'-yl 2-bromo-5-isopropoxy-1-benzoate (218932-20-8)

Guidance literature:

With triethylamine; Yield given;

DOI:10.1055/s-1998-1912

upstream raw materials:

(1R,3R)-N-benzyl-6-hydroxy-8-isopropoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline

Downstream raw materials:

(2R,4R)-3-Benzyl-5,10-diisopropoxy-2,4-dimethyl-1,2,3,4-tetrahydro-7-oxa-3-aza-benzo[c]phenanthren-8-one