1β-[2,4-bis(benzoylamino)pyrimidin-5-yl]-1,2-dideoxy-5-O-(4,4’-dimethoxytriphenylmethyl)-D-ribofuranose-3-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite

Base Information

Chemical Name:1β-[2,4-bis(benzoylamino)pyrimidin-5-yl]-1,2-dideoxy-5-O-(4,4’-dimethoxytriphenylmethyl)-D-ribofuranose-3-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite
CAS No.:1422959-06-5
Molecular Formula:C₅₃H₅₇N₆O₈P
Molecular Weight:937.045
Hs Code.:

1β-[2,4-bis(benzoylamino)pyrimidin-5-yl]-1,2-dideoxy-5-O-(4,4’-dimethoxytriphenylmethyl)-D-ribofuranose-3-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite

Synonyms:1β-[2,4-bis(benzoylamino)pyrimidin-5-yl]-1,2-dideoxy-5-O-(4,4’-dimethoxytriphenylmethyl)-D-ribofuranose-3-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite

Suppliers and Price of 1β-[2,4-bis(benzoylamino)pyrimidin-5-yl]-1,2-dideoxy-5-O-(4,4’-dimethoxytriphenylmethyl)-D-ribofuranose-3-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1β-[2,4-bis(benzoylamino)pyrimidin-5-yl]-1,2-dideoxy-5-O-(4,4’-dimethoxytriphenylmethyl)-D-ribofuranose-3-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1β-[2,4-bis(benzoylamino)pyrimidin-5-yl]-1,2-dideoxy-5-O-(4,4’-dimethoxytriphenylmethyl)-D-ribofuranose-3-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite

There total 9 articles about 1β-[2,4-bis(benzoylamino)pyrimidin-5-yl]-1,2-dideoxy-5-O-(4,4’-dimethoxytriphenylmethyl)-D-ribofuranose-3-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1422959-05-4
1β-[2,4-bis(benzoylamino)pyrimidin-5-yl]-1,2-dideoxy-5-O-(4,4′-dimethoxytriphenylmethyl)-D-ribofuranose

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1422959-06-5
1β-[2,4-bis(benzoylamino)pyrimidin-5-yl]-1,2-dideoxy-5-O-(4,4’-dimethoxytriphenylmethyl)-D-ribofuranose-3-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere; Schlenk technique;
DOI:10.1002/chem.201904623

Reference yield:

: 1422959-02-1
1β-(2,4-dichloropyrimidin-5-yl)-1,2-dideoxy-5-O-(tert-butyl-dimethylsilyl)-D-ribofuranose

: 1422959-06-5
1β-[2,4-bis(benzoylamino)pyrimidin-5-yl]-1,2-dideoxy-5-O-(4,4’-dimethoxytriphenylmethyl)-D-ribofuranose-3-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 100 °C / Inert atmosphere; Schlenk technique

2: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

3: pyridine / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere; Schlenk technique

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere; Schlenk technique

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1: |Buchwald-Hartwig Coupling;
DOI:10.1021/jo302768f

Reference yield:

: 1422959-03-2
1β-[2,4-bis(benzoylamino)pyrimidin-5-yl]-1,2-dideoxy-5-O-(tert-butyl-dimethylsilyl)-D-ribofuranose

: 1422959-06-5
1β-[2,4-bis(benzoylamino)pyrimidin-5-yl]-1,2-dideoxy-5-O-(4,4’-dimethoxytriphenylmethyl)-D-ribofuranose-3-[(2-cyanoethyl)(N,N-diisopropyl)]phosphoramidite

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2: pyridine / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere; Schlenk technique

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere; Schlenk technique

With pyridine; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo302768f