1-<(4-nitrophenyl)sulfonyl>-2-methyl-3-(triphenylmethyl)-sn-glycerol

Base Information

• Chemical Name: 1-<(4-nitrophenyl)sulfonyl>-2-methyl-3-(triphenylmethyl)-sn-glycerol
• CAS No.: 116150-01-7
• Molecular Formula: C₂₉H₂₇NO₇S
• Molecular Weight: 533.602
• Mol file: 116150-01-7.mol

Synonyms:1-<(4-nitrophenyl)sulfonyl>-2-methyl-3-(triphenylmethyl)-sn-glycerol

Chemical Property of 1-<(4-nitrophenyl)sulfonyl>-2-methyl-3-(triphenylmethyl)-sn-glycerol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<(4-nitrophenyl)sulfonyl>-2-methyl-3-(triphenylmethyl)-sn-glycerol

There total 4 articles about 1-<(4-nitrophenyl)sulfonyl>-2-methyl-3-(triphenylmethyl)-sn-glycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(R)-2-methoxy-3-(trityloxy)propan-1-ol (111247-98-4) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → 1-<(4-nitrophenyl)sulfonyl>-2-methyl-3-(triphenylmethyl)-sn-glycerol (116150-01-7)

Guidance literature:

With dmap; In chloroform; for 16h; Ambient temperature;

DOI:10.1021/jo00256a024

Reference yield:

methyl (2S)-2-hydroxy-3-(triphenylmethoxy)propanoate (111247-96-2) → 1-<(4-nitrophenyl)sulfonyl>-2-methyl-3-(triphenylmethyl)-sn-glycerol (116150-01-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / silver tetrafluoroborate, silver carbonate / acetonitrile / 72 h / Ambient temperature

2: 82 percent / LiAlH₄ / diethyl ether / 1.) 0 deg C, 30 min, 2.) RT, 2 h

3: 83 percent / 4-(dimethylamino)pyridine (DMAP) / CHCl₃ / 16 h / Ambient temperature

With dmap; lithium aluminium tetrahydride; silver tetrafluoroborate; silver carbonate; In diethyl ether; chloroform; acetonitrile;

DOI:10.1021/jo00256a024

Reference yield:

N-tritylpyridinium tetrafluoroborate (26156-84-3) → 1-<(4-nitrophenyl)sulfonyl>-2-methyl-3-(triphenylmethyl)-sn-glycerol (116150-01-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / acetonitrile / 24 h / Ambient temperature

2: 84 percent / silver tetrafluoroborate, silver carbonate / acetonitrile / 72 h / Ambient temperature

3: 82 percent / LiAlH₄ / diethyl ether / 1.) 0 deg C, 30 min, 2.) RT, 2 h

4: 83 percent / 4-(dimethylamino)pyridine (DMAP) / CHCl₃ / 16 h / Ambient temperature

With dmap; lithium aluminium tetrahydride; silver tetrafluoroborate; silver carbonate; In diethyl ether; chloroform; acetonitrile;

DOI:10.1021/jo00256a024

upstream raw materials:

(R)-2-methoxy-3-(trityloxy)propan-1-ol

4-Nitrobenzenesulfonyl chloride

methyl (2S)-2-hydroxy-3-(triphenylmethoxy)propanoate

N-tritylpyridinium tetrafluoroborate

Downstream raw materials:

1-S-octadecyl-2-methyl-3-(triphenylmethyl)-sn-thioglycerol

2-methyl-3-(triphenylmethyl)-sn-thioglycerol

1-S-(methylcarbonyl)-2-methyl-3-(triphenylmethyl)-sn-thioglycerol