5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

Base Information

Chemical Name:5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene
CAS No.:141667-51-8
Molecular Formula:C₂₁H₃₁NO₄SSi
Molecular Weight:421.633
Hs Code.:

Synonyms:5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

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Chemical Property of 5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

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Technology Process of 5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

There total 7 articles about 5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 141667-50-7
5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-4-(4-methylbenzenesulfenyl)-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

: 141667-51-8
5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

Guidance literature:: With 2,2'-azobis(isobutyronitrile); In benzene; for 2h; Heating;
DOI:10.1021/jo00041a010

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 141667-51-8
5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 0.08 h / 0 °C

2: 89 percent / Bu₃Sn, azobisisobutyronitrile / benzene / 2 h / Heating

With 2,2'-azobis(isobutyronitrile); triethylamine; In dichloromethane; benzene;
DOI:10.1021/jo00041a010

Reference yield:

: 107383-65-3
3-(4-methylbenzenesulfenyl)-2-pyridone

: 141667-51-8
5-endo-<<(tert-butyldimethylsilyl)oxy>methyl>-2-(4'-methylbenzenesulfonyl)-3-oxo-2-azabicyclo<2.2.2>oct-7-ene

Guidance literature:: Multi-step reaction with 5 steps

1: 1) lithium hexamethyldisilazide / 1) THF, hexane, 0 deg C, 2) THF, hexane

2: 42 percent / CH₂Cl₂ / 120 h / 90 °C

3: 93 percent / NaBH₄ / CH₂Cl₂; methanol / 0.25 h / 0 °C

4: 95 percent / Et₃N / CH₂Cl₂ / 0.08 h / 0 °C

5: 89 percent / Bu₃Sn, azobisisobutyronitrile / benzene / 2 h / Heating

With sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); triethylamine; lithium hexamethyldisilazane; In methanol; dichloromethane; benzene;
DOI:10.1021/jo00041a010