6-(4-methoxyphenyl)-3,3-dimethylhex-5-ynoic acid pyridin-2-yl ester

Base Information

• Chemical Name: 6-(4-methoxyphenyl)-3,3-dimethylhex-5-ynoic acid pyridin-2-yl ester
• CAS No.: 867339-20-6
• Molecular Formula: C₂₀H₂₁NO₃
• Molecular Weight: 323.392
• Mol file: 867339-20-6.mol

Synonyms:6-(4-methoxyphenyl)-3,3-dimethylhex-5-ynoic acid pyridin-2-yl ester

Chemical Property of 6-(4-methoxyphenyl)-3,3-dimethylhex-5-ynoic acid pyridin-2-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 6-(4-methoxyphenyl)-3,3-dimethylhex-5-ynoic acid pyridin-2-yl ester

There total 2 articles about 6-(4-methoxyphenyl)-3,3-dimethylhex-5-ynoic acid pyridin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(4-methoxy-phenyl)-3,3-dimethyl-hex-5-ynoic acid → 6-(4-methoxyphenyl)-3,3-dimethylhex-5-ynoic acid pyridin-2-yl ester (867339-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

With thionyl chloride;

DOI:10.1021/ol0514956

Reference yield:

6-(4-methoxy-phenyl)-3,3-dimethyl-hex-5-ynoyl chloride + 2-hydroxypyridin (142-08-5) → 6-(4-methoxyphenyl)-3,3-dimethylhex-5-ynoic acid pyridin-2-yl ester (867339-20-6)

Guidance literature:

DOI:10.1021/ol0514956

Reference yield: 66.0%

6-(4-methoxyphenyl)-3,3-dimethylhex-5-ynoic acid pyridin-2-yl ester (867339-20-6) + carbon monoxide (201230-82-2) → 3-(4-methoxyphenyl)-5,5-dimethyl-4,5-dihydro-2H-cyclopenta[b]furan-2-one

Guidance literature:

With dicyclohexylmethylamine; triphenylphosphine; bis(η3-allyl-μ-chloropalladium(II)); In toluene; at 120 ℃; for 20h; under 760 Torr;

DOI:10.1021/ol0514956

upstream raw materials:

2-hydroxypyridin