benzyl [(1R)-1-(2-{5-bromo-2-[(ethylcarbamoyl)amino]pyridin-4-yl}-1,3-thiazol-4-yl)-2-methylpropyl]carbamate

Base Information

Chemical Name:benzyl [(1R)-1-(2-{5-bromo-2-[(ethylcarbamoyl)amino]pyridin-4-yl}-1,3-thiazol-4-yl)-2-methylpropyl]carbamate
CAS No.:1258214-09-3
Molecular Formula:C₂₃H₂₆BrN₅O₃S
Molecular Weight:532.461
Hs Code.:

Synonyms:benzyl [(1R)-1-(2-{5-bromo-2-[(ethylcarbamoyl)amino]pyridin-4-yl}-1,3-thiazol-4-yl)-2-methylpropyl]carbamate

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Chemical Property of benzyl [(1R)-1-(2-{5-bromo-2-[(ethylcarbamoyl)amino]pyridin-4-yl}-1,3-thiazol-4-yl)-2-methylpropyl]carbamate

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Technology Process of benzyl [(1R)-1-(2-{5-bromo-2-[(ethylcarbamoyl)amino]pyridin-4-yl}-1,3-thiazol-4-yl)-2-methylpropyl]carbamate

There total 4 articles about benzyl [(1R)-1-(2-{5-bromo-2-[(ethylcarbamoyl)amino]pyridin-4-yl}-1,3-thiazol-4-yl)-2-methylpropyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.4%

: 1031432-71-9
5-bromo-2-(3-ethylureido)pyridine-4-carbothioamide

: 1258214-10-6
benzyl [(3R)-1-bromo-4-methyl-2-oxopentan-3-yl]carbamate

: 1258214-09-3
benzyl [(1R)-1-(2-{5-bromo-2-[(ethylcarbamoyl)amino]pyridin-4-yl}-1,3-thiazol-4-yl)-2-methylpropyl]carbamate

Guidance literature:: In acetonitrile; for 48h; Reflux;

Reference yield:

: 1685-33-2
N-[(benzyloxy)carbonyl]-D-valine

: 1258214-09-3
benzyl [(1R)-1-(2-{5-bromo-2-[(ethylcarbamoyl)amino]pyridin-4-yl}-1,3-thiazol-4-yl)-2-methylpropyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran; diethyl ether / 0.83 h / -20 - -10 °C

2: diethyl ether / 2 h / -60 - 26 °C

3: hydrogen bromide; acetic acid / 0.5 h / 0 °C

4: acetonitrile / 48 h / Reflux

With hydrogen bromide; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; acetonitrile;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1258214-09-3
benzyl [(1R)-1-(2-{5-bromo-2-[(ethylcarbamoyl)amino]pyridin-4-yl}-1,3-thiazol-4-yl)-2-methylpropyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water / 2 h / 0 - 26 °C / pH 8 - 9

1.2: 5 - 10 °C / pH 1 - 2

2.1: triethylamine / tetrahydrofuran; diethyl ether / 0.83 h / -20 - -10 °C

3.1: diethyl ether / 2 h / -60 - 26 °C

4.1: hydrogen bromide; acetic acid / 0.5 h / 0 °C

5.1: acetonitrile / 48 h / Reflux

With hydrogen bromide; acetic acid; triethylamine; sodium hydroxide; In tetrahydrofuran; diethyl ether; water; acetonitrile;