6-(4-(4-((R)-1-(benzyloxycarbonylamino)-2-methylpropyl)thiazol-2-yl)-6-(3-ethylureido)pyridin-3-yl)-1-((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

Chemical Name:6-(4-(4-((R)-1-(benzyloxycarbonylamino)-2-methylpropyl)thiazol-2-yl)-6-(3-ethylureido)pyridin-3-yl)-1-((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No.:1258214-04-8
Molecular Formula:C₃₉H₄₄N₆O₇S
Molecular Weight:740.88
Hs Code.:

6-(4-(4-((R)-1-(benzyloxycarbonylamino)-2-methylpropyl)thiazol-2-yl)-6-(3-ethylureido)pyridin-3-yl)-1-((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Synonyms:6-(4-(4-((R)-1-(benzyloxycarbonylamino)-2-methylpropyl)thiazol-2-yl)-6-(3-ethylureido)pyridin-3-yl)-1-((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Chemical Property of 6-(4-(4-((R)-1-(benzyloxycarbonylamino)-2-methylpropyl)thiazol-2-yl)-6-(3-ethylureido)pyridin-3-yl)-1-((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

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Technology Process of 6-(4-(4-((R)-1-(benzyloxycarbonylamino)-2-methylpropyl)thiazol-2-yl)-6-(3-ethylureido)pyridin-3-yl)-1-((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 13 articles about 6-(4-(4-((R)-1-(benzyloxycarbonylamino)-2-methylpropyl)thiazol-2-yl)-6-(3-ethylureido)pyridin-3-yl)-1-((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₁H₄₈N₆O₇S

: 1258214-04-8
6-(4-(4-((R)-1-(benzyloxycarbonylamino)-2-methylpropyl)thiazol-2-yl)-6-(3-ethylureido)pyridin-3-yl)-1-((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: C₄₁H₄₈N₆O₇S; With water; lithium hydroxide; In 1,4-dioxane; at 100 ℃; for 9h;

With hydrogenchloride; In 1,4-dioxane; water; at 23 ℃; pH=3 - 4;

Reference yield:

: 1258214-05-9
(S)-ethyl 1-(1-hydroxy-3,3-dimethylbutan-2-yl)-4-oxo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4-dihydroquinoline-3-carboxylate

: 1258214-04-8
6-(4-(4-((R)-1-(benzyloxycarbonylamino)-2-methylpropyl)thiazol-2-yl)-6-(3-ethylureido)pyridin-3-yl)-1-((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 100 °C

2.1: water; lithium hydroxide / 1,4-dioxane / 9 h / 100 °C

2.2: 23 °C / pH 3 - 4

With water; caesium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; 1.1: Suzuki Coupling;

Reference yield:

: 28094-73-7
1-diazo-2-oxo-(3R)-3-benzyloxycarbonylamino-4-methylpentane

: 1258214-04-8
6-(4-(4-((R)-1-(benzyloxycarbonylamino)-2-methylpropyl)thiazol-2-yl)-6-(3-ethylureido)pyridin-3-yl)-1-((S)-1-hydroxy-3,3-dimethylbutan-2-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen bromide; acetic acid / 0.5 h / 0 °C

2.1: acetonitrile / 48 h / Reflux

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 100 °C

4.1: water; lithium hydroxide / 1,4-dioxane / 9 h / 100 °C

4.2: 23 °C / pH 3 - 4

With water; hydrogen bromide; caesium carbonate; acetic acid; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; acetonitrile; 3.1: Suzuki Coupling;