2,3-Dibromo-5-fluorotoluene

Base Information

• Chemical Name: 2,3-Dibromo-5-fluorotoluene
• CAS No.: 1000576-64-6
• Molecular Formula: C₇H₅Br₂F
• Molecular Weight: 267.923
• Mol file: 1000576-64-6.mol

Synonyms:1,2-dibromo-5-fluoro-3-methylbenzene

Chemical Property of 2,3-Dibromo-5-fluorotoluene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dibromo-5-fluorotoluene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-Dibromo-5-fluorotoluene

There total 2 articles about 2,3-Dibromo-5-fluorotoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ 1,2-dibromo-5-fluoro-3-methylbenzene (1000576-64-6)

Guidance literature:

With hydrogenchloride; In water; at 60 - 70 ℃; for 1h;

With sodium nitrite; In water; at 0 - 5 ℃; for 0.25h;

With hydrogenchloride; copper(l) chloride; In water; at 70 - 80 ℃; for 0.5h;

Reference yield:

2-bromo-4-fluoro-6-methylaniline hydrochloride (1319196-59-2) → 1,2-dibromo-5-fluoro-3-methylbenzene (1000576-64-6)

Guidance literature:

2-bromo-4-fluoro-6-methylaniline hydrochloride; With hydrogen bromide; sodium nitrite; In ethanol; water; at 0 ℃; for 0.416667h;

With hydrogen bromide; copper(I) bromide; In ethanol; water; at 70 ℃; for 3h;

Reference yield: 61.7%

N-Formylpiperidine (2591-86-8) + 1,2-dibromo-5-fluoro-3-methylbenzene (1000576-64-6) → 2-bromo-5-fluoro-3-methylbenzaldehyde

Guidance literature:

1,2-dibromo-5-fluoro-3-methylbenzene; With isopropylmagnesium bromide; In tetrahydrofuran; at 0 ℃; for 1h;

N-Formylpiperidine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

upstream raw materials:

2-bromo-4-fluoro-6-methylaniline hydrochloride

Downstream raw materials:

2-bromo-5-fluoro-3-methylbenzoic acid

(2-bromo-5-fluoro-3-methylphenyl)(pyrrolidin-1-yl)methanone

Refernces

• 1、 -. "AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE". Page/Page column 57; 58. . Retrieved 2011/08/08.