4-amino-4-deoxy-9-methyl-10-deazapteroic acid

Base Information

Chemical Name:4-amino-4-deoxy-9-methyl-10-deazapteroic acid
CAS No.:122594-31-4
Molecular Formula:C₁₆H₁₆N₆O₂
Molecular Weight:324.342
Hs Code.:

Synonyms:4-amino-4-deoxy-9-methyl-10-deazapteroic acid

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Chemical Property of 4-amino-4-deoxy-9-methyl-10-deazapteroic acid

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Technology Process of 4-amino-4-deoxy-9-methyl-10-deazapteroic acid

There total 9 articles about 4-amino-4-deoxy-9-methyl-10-deazapteroic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 122594-29-0
methyl 4-amino-4-deoxy-9-methyl-10-deazapteroate

: 122594-31-4
4-amino-4-deoxy-9-methyl-10-deazapteroic acid

Guidance literature:: With sodium hydroxide; In 2-methoxy-ethanol; for 44h; Ambient temperature;
DOI:10.1021/jm00163a035

Reference yield:

: 122594-17-6
2-methyl-p-carbomethoxyhydrocinnamic acid

: 122594-31-4
4-amino-4-deoxy-9-methyl-10-deazapteroic acid

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂ / benzene / 2.5 h / Heating

2: 2.) HCl(gas) / 1.) Et₂O, 0-5 deg C, 1h, 2.) 15 h

3: 94 percent / NaN₃ / methanol; H₂O / 18 h / Ambient temperature

4: 83 percent / H₂, conc. HCl / Pd / ethanol / 6 h

5: 83 percent / NaOMe, s-collidine / methanol; dimethylformamide / 0.5 h / 90 °C

6: 1.) Zn, HOAc, 2.) H₂O₂ / 1.) 100 deg C, 4 h, 2.) H₂O, 15 h

7: 94 percent / 10percent NaOH / 2-methoxy-ethanol / 44 h / Ambient temperature

With 2,4,6-trimethyl-pyridine; hydrogenchloride; sodium hydroxide; thionyl chloride; sodium azide; hydrogen; dihydrogen peroxide; sodium methylate; acetic acid; zinc; palladium; In methanol; ethanol; 2-methoxy-ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00163a035

Reference yield:

: 122594-19-8
4-(2-Chlorocarbonyl-propyl)-benzoic acid methyl ester

: 122594-31-4
4-amino-4-deoxy-9-methyl-10-deazapteroic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 2.) HCl(gas) / 1.) Et₂O, 0-5 deg C, 1h, 2.) 15 h

2: 94 percent / NaN₃ / methanol; H₂O / 18 h / Ambient temperature

3: 83 percent / H₂, conc. HCl / Pd / ethanol / 6 h

4: 83 percent / NaOMe, s-collidine / methanol; dimethylformamide / 0.5 h / 90 °C

5: 1.) Zn, HOAc, 2.) H₂O₂ / 1.) 100 deg C, 4 h, 2.) H₂O, 15 h

6: 94 percent / 10percent NaOH / 2-methoxy-ethanol / 44 h / Ambient temperature

With 2,4,6-trimethyl-pyridine; hydrogenchloride; sodium hydroxide; sodium azide; hydrogen; dihydrogen peroxide; sodium methylate; acetic acid; zinc; palladium; In methanol; ethanol; 2-methoxy-ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a035