3-methyl-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

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Chemical Name:3-methyl-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione
CAS No.:1384248-77-4
Molecular Formula:C₂₁H₂₂N₄O₃
Molecular Weight:378.431
Hs Code.:

Synonyms:3-methyl-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

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Chemical Property of 3-methyl-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

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Technology Process of 3-methyl-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

There total 4 articles about 3-methyl-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 123-75-1
pyrrolidine

: 1384248-67-2
methyl 2-(3-methyl-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[f][1,3,5]triazepin-1-yl)acetate

: 1384248-77-4
3-methyl-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

Guidance literature:: at 150 ℃; for 0.5h; Microwave irradiation; Neat (no solvent);
DOI:10.1016/j.tetlet.2012.05.025

Reference yield:

: 872539-37-2
tert-butyl N-(2-anilinophenyl)glycinate

: 1384248-77-4
3-methyl-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,4-dichlorophenoxyacetic acid dimethylamine / 0.5 h / 150 °C / Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

2.2: 16 h

3.1: 0.5 h / 150 °C / Microwave irradiation; Neat (no solvent)

With sodium hydride; In 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetlet.2012.05.025

Reference yield:

: 62-53-3
aniline

: 1384248-77-4
3-methyl-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-5-phenyl-1H-benzo[f][1,3,5]triazepine-2,4(3H,5H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: 0.25 h / 170 °C / Microwave irradiation; Neat (no solvent)

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 65 °C

4.1: 2,4-dichlorophenoxyacetic acid dimethylamine / 0.5 h / 150 °C / Microwave irradiation

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C

5.2: 16 h

6.1: 0.5 h / 150 °C / Microwave irradiation; Neat (no solvent)

With palladium 10% on activated carbon; hydrogen; sodium hydride; potassium carbonate; In ethanol; 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetlet.2012.05.025