1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide

Base Information

Chemical Name:1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide
CAS No.:1338377-28-8
Molecular Formula:C₂₂H₂₄N₆O
Molecular Weight:388.472
Hs Code.:

Synonyms:1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide

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Chemical Property of 1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide

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Technology Process of 1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide

There total 6 articles about 1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1338377-24-4
7-chloro-1-(cyclohexylamino)-5H-pyrido[4,3-b]indole-4-carboxamide

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1338377-28-8
1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; at 100 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm200909u

Reference yield:

: 1338377-60-8
7-chloro-1-(cyclohexylamino)-5H-pyrido[4,3-b]indole-4-carbonitrile

: 1338377-28-8
1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 16 h / 70 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; tricyclohexylphosphine / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dihydrogen peroxide; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; water; dimethyl sulfoxide;
DOI:10.1021/jm200909u

Reference yield:

: 2312-23-4
m-chlorophenylhydrazine hydrochloride

: 1338377-28-8
1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water

2.1: diphenylether / 4 h / 175 - 230 °C

2.2: 5 - 20 °C

3.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 16 h / 70 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; tricyclohexylphosphine / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dihydrogen peroxide; potassium carbonate; sodium hydroxide; tricyclohexylphosphine; In 1,4-dioxane; diphenylether; water; dimethyl sulfoxide;
DOI:10.1021/jm200909u