N-[3-fluoro-4-[6-methoxy-7-[3-(tetrahydropyrrol-1-yl)propyloxy]quinolin-4-oxy]phenyl]-2-phenyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide

Base Information

Chemical Name:N-[3-fluoro-4-[6-methoxy-7-[3-(tetrahydropyrrol-1-yl)propyloxy]quinolin-4-oxy]phenyl]-2-phenyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide
CAS No.:1456774-90-5
Molecular Formula:C₃₄H₃₃FN₆O₆
Molecular Weight:640.671
Hs Code.:

N-[3-fluoro-4-[6-methoxy-7-[3-(tetrahydropyrrol-1-yl)propyloxy]quinolin-4-oxy]phenyl]-2-phenyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide

Synonyms:N-[3-fluoro-4-[6-methoxy-7-[3-(tetrahydropyrrol-1-yl)propyloxy]quinolin-4-oxy]phenyl]-2-phenyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide

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Chemical Property of N-[3-fluoro-4-[6-methoxy-7-[3-(tetrahydropyrrol-1-yl)propyloxy]quinolin-4-oxy]phenyl]-2-phenyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide

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Technology Process of N-[3-fluoro-4-[6-methoxy-7-[3-(tetrahydropyrrol-1-yl)propyloxy]quinolin-4-oxy]phenyl]-2-phenyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide

There total 13 articles about N-[3-fluoro-4-[6-methoxy-7-[3-(tetrahydropyrrol-1-yl)propyloxy]quinolin-4-oxy]phenyl]-2-phenyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.2%

: 1394166-11-0
3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)aniline

: 1456775-94-2
2-phenyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonyl chloride

: 1456774-90-5
N-[3-fluoro-4-[6-methoxy-7-[3-(tetrahydropyrrol-1-yl)propyloxy]quinolin-4-oxy]phenyl]-2-phenyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 10h;

Reference yield:

: 1160707-44-7
1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one

: 1456774-90-5
N-[3-fluoro-4-[6-methoxy-7-[3-(tetrahydropyrrol-1-yl)propyloxy]quinolin-4-oxy]phenyl]-2-phenyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 16 h / Reflux

2.1: iron; acetic acid / 2 h / 80 °C

2.2: 0.5 h / 80 °C

3.1: acetonitrile / 8 h / Reflux

4.1: trichlorophosphate / acetonitrile / 6 h / 85 °C

5.1: chlorobenzene / 20 h / 145 °C

6.1: iron; hydrogenchloride / ethanol; water / 2 h / Reflux

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 20 °C

With hydrogenchloride; iron; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; dichloromethane; water; chlorobenzene; toluene; acetonitrile;

Reference yield:

: 1394166-08-5
(Ε)-1-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)propyl-2-en-1-one

: 1456774-90-5
N-[3-fluoro-4-[6-methoxy-7-[3-(tetrahydropyrrol-1-yl)propyloxy]quinolin-4-oxy]phenyl]-2-phenyl-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: iron; acetic acid / 2 h / 80 °C

1.2: 0.5 h / 80 °C

2.1: acetonitrile / 8 h / Reflux

3.1: trichlorophosphate / acetonitrile / 6 h / 85 °C

4.1: chlorobenzene / 20 h / 145 °C

5.1: iron; hydrogenchloride / ethanol; water / 2 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h / 20 °C

With hydrogenchloride; iron; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; dichloromethane; water; chlorobenzene; acetonitrile;