ethyl 5-bromo-3-[2-(3-methoxy-2-isopropoxyphenyl)ethyl]-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate

Base Information

Chemical Name:ethyl 5-bromo-3-[2-(3-methoxy-2-isopropoxyphenyl)ethyl]-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate
CAS No.:851541-38-3
Molecular Formula:C₂₃H₃₂BrNO₅
Molecular Weight:482.415
Hs Code.:

Synonyms:ethyl 5-bromo-3-[2-(3-methoxy-2-isopropoxyphenyl)ethyl]-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate

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Chemical Property of ethyl 5-bromo-3-[2-(3-methoxy-2-isopropoxyphenyl)ethyl]-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate

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Technology Process of ethyl 5-bromo-3-[2-(3-methoxy-2-isopropoxyphenyl)ethyl]-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate

There total 1 articles about ethyl 5-bromo-3-[2-(3-methoxy-2-isopropoxyphenyl)ethyl]-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 30132-23-1
ethyl 3-bromo-2-oxocyclohexanecarboxylate

: 2-(3-methoxy-2-isopropoxyphenyl)ethylamine

: 851541-38-3
ethyl 5-bromo-3-[2-(3-methoxy-2-isopropoxyphenyl)ethyl]-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate

Guidance literature:: In dichloromethane; water; at 0 - 20 ℃; for 21h;
DOI:10.1016/j.tet.2005.02.014

Reference yield: 66.0%

: 851541-38-3
ethyl 5-bromo-3-[2-(3-methoxy-2-isopropoxyphenyl)ethyl]-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate

: 108-24-7
acetic anhydride

: ethyl 5-bromo-3-[2-(3-methoxy-2-acetoxyphenyl)ethyl]-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; for 0.166667h;
DOI:10.1016/j.tet.2005.02.014

Reference yield:

: 851541-38-3
ethyl 5-bromo-3-[2-(3-methoxy-2-isopropoxyphenyl)ethyl]-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate

: ethyl 5-hydroxy-3-[2-(3-methoxy-2-acetoxyphenyl)ethyl]-9-oxo-3-azabicyclo[3.3.1]nonane-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 0.17 h

2: 82 percent / silver 2,4,6-trinitrobenzenesulfonate / nitromethane / 24 h / cooling

With trimethylsilyl trifluoromethanesulfonate; silver 2,4,6-trinitrobenzenesulfonate; In nitromethane; acetonitrile;
DOI:10.1016/j.tet.2005.02.014