Technology Process of 5-O-tert-butyldimethylsilyl-4-C-(2-(4-methoxyphenoxy)ethyl)-2,3-dideoxy-D-glycero-pentono-1,4-lactone
There total 9 articles about 5-O-tert-butyldimethylsilyl-4-C-(2-(4-methoxyphenoxy)ethyl)-2,3-dideoxy-D-glycero-pentono-1,4-lactone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
DOI:10.1016/j.ejmech.2003.10.006
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 84 percent / imidazole; 4-dimethylaminopyridine / CH2Cl2 / 14 h / 20 °C
2: 99 percent / 4-dimethylaminopyridine / CH2Cl2 / 3 h / 20 °C
3: 95 percent / AIBN; tributyltin hydride / toluene / 1 h / 90 °C
4: 95 percent / acetic acid; H2 / palladium on carbon / ethyl acetate / 6 h
5: 90 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C
With
1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; acetic acid; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; ethyl acetate; toluene;
3: Barton deoxygenation;
DOI:10.1016/j.ejmech.2003.10.006
- Guidance literature:
-
Multi-step reaction with 8 steps
1: Dowex H1+ resin / tetrahydrofuran; H2O / 24 h / Heating
2: sodium periodate / methanol; H2O / 1 h / 20 °C
3: 5 g / sodium borohydride / methanol / 0 °C
4: 84 percent / imidazole; 4-dimethylaminopyridine / CH2Cl2 / 14 h / 20 °C
5: 99 percent / 4-dimethylaminopyridine / CH2Cl2 / 3 h / 20 °C
6: 95 percent / AIBN; tributyltin hydride / toluene / 1 h / 90 °C
7: 95 percent / acetic acid; H2 / palladium on carbon / ethyl acetate / 6 h
8: 90 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C
With
1H-imidazole; dmap; sodium tetrahydroborate; sodium periodate; 2,2'-azobis(isobutyronitrile); Dowex H1+ resin; hydrogen; tri-n-butyl-tin hydride; acetic acid; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene;
6: Barton deoxygenation;
DOI:10.1016/j.ejmech.2003.10.006
