Technology Process of C22H31N3O6
There total 4 articles about C22H31N3O6 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(tert-butoxycarbonyl)-L-proline;
With
chloroformic acid ethyl ester; triethylamine;
In
tetrahydrofuran;
at 0 ℃;
for 0.416667h;
Inert atmosphere;
N-(2-aminobenzoyl)-α-methylalanine methyl ester;
In
tetrahydrofuran;
for 8h;
Inert atmosphere;
Reflux;
DOI:10.1021/ol4002762
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 5 h / 20 °C / Cooling with ice
2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 3102.97 Torr
3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere
3.2: 8 h / Inert atmosphere; Reflux
With
palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; triethylamine;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ol4002762
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / 3102.97 Torr
2.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere
2.2: 8 h / Inert atmosphere; Reflux
With
palladium 10% on activated carbon; hydrogen; chloroformic acid ethyl ester; triethylamine;
In
tetrahydrofuran; ethyl acetate;
DOI:10.1021/ol4002762
