3-(4-methoxyphenyl)-N-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]propanamide

Base Information

• Chemical Name: 3-(4-methoxyphenyl)-N-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]propanamide
• CAS No.: 856439-24-2
• Molecular Formula: C₁₈H₃₁NO₃Si
• Molecular Weight: 337.535
• Mol file: 856439-24-2.mol

Synonyms:3-(4-methoxyphenyl)-N-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]propanamide

Chemical Property of 3-(4-methoxyphenyl)-N-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methoxyphenyl)-N-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]propanamide

There total 2 articles about 3-(4-methoxyphenyl)-N-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

3-(4-methoxyphenyl)propanoic acid (1929-29-9) + 2‐((tert‐butyldimethylsilyl)oxy)ethan‐1‐amine (101711-55-1) → 3-(4-methoxyphenyl)-N-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]propanamide (856439-24-2)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.bmc.2005.03.004

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 3-(4-methoxyphenyl)-N-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]propanamide (856439-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h

2: 42 percent / triethylamine; N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 5 h / 20 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1016/j.bmc.2005.03.004

Reference yield: 100.0%

3-(4-methoxyphenyl)-N-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]propanamide (856439-24-2) → N-(2-hydroxyethyl)-3-(4-methoxyphenyl)propanamide (856439-25-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 1h;

DOI:10.1016/j.bmc.2005.03.004

upstream raw materials:

3-(4-methoxyphenyl)propanoic acid

2‐((tert‐butyldimethylsilyl)oxy)ethan‐1‐amine

tert-butyldimethylsilyl chloride

Downstream raw materials:

N-(2-hydroxyethyl)-3-(4-methoxyphenyl)propanamide

2-[3-(4-methoxyphenyl)propylamino]ethanol