Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-[(4-methoxyphenyl)methyl]-8-(phenylmethyl)-

Base Information

Chemical Name:Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-[(4-methoxyphenyl)methyl]-8-(phenylmethyl)-
CAS No.:276879-69-7
Molecular Formula:C27H23 N3 O3
Molecular Weight:437.498
Hs Code.:
Mol file:276879-69-7.mol

Synonyms:Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-[(4-methoxyphenyl)methyl]-8-(phenylmethyl)-

Suppliers and Price of Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-[(4-methoxyphenyl)methyl]-8-(phenylmethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-[(4-methoxyphenyl)methyl]-8-(phenylmethyl)-

Chemical Property:

Boiling Point:621.5±65.0 °C(Predicted)
PKA:10.50±0.30(Predicted)
PSA：79.62000
Density:1.26±0.1 g/cm3(Predicted)
LogP:4.58540

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-[(4-methoxyphenyl)methyl]-8-(phenylmethyl)-

There total 7 articles about Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-[(4-methoxyphenyl)methyl]-8-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.9%

: 37156-84-6
4-(5-amino-6-benzyl-pyrazin-2-yl)-phenol

: 1,1-diethoxy-3-(4-methoxyphenyl)propan-2-one

: 276879-69-7
2-(p-methoxybenzyl)-6-(p-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 0 - 100 ℃; for 17h; Inert atmosphere;

Reference yield:

: 37156-84-6
4-(5-amino-6-benzyl-pyrazin-2-yl)-phenol

: 2-(4-methoxy-benzyl)-[1,3]dioxolane-2-carbaldehyde

: 276879-69-7
2-(p-methoxybenzyl)-6-(p-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 80 ℃; for 1.5h;
DOI:10.1016/S0040-4020(00)00163-0

Reference yield:

: 117535-79-2
(E)-1-(4-methoxyphenyl)-4-phenylbut-3-en-2-one

: 276879-69-7
2-(p-methoxybenzyl)-6-(p-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo[1,2-a]pyrazine-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / TsOH / ethane-1,2-diol; benzene / 4.5 h / Heating

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: Et₃N / CH₂Cl₂ / 1 h / 20 °C

3.1: HCl / dioxane; H₂O / 1.5 h / 80 °C

With hydrogenchloride; toluene-4-sulfonic acid; ozone; In 1,4-dioxane; dichloromethane; water; ethylene glycol; benzene; 1.1: acetal formation / 2.1: Oxidation / 2.2: Substitution / 3.1: Cyclization;
DOI:10.1016/S0040-4020(00)00163-0