3-O-Benzyl-17β-Dihydro Equilin

Base Information

• Chemical Name: 3-O-Benzyl-17β-Dihydro Equilin
• CAS No.: 26789-44-6
• Molecular Formula: C₂₅H₂₆O₃
• Molecular Weight: 374.48
• Mol file: 26789-44-6.mol

Synonyms:1,3,5(10),7-estratetraene-3,17β-diol 3-benzoate

Chemical Property of 3-O-Benzyl-17β-Dihydro Equilin

Chemical Property:

• Boiling Point: 540.5±50.0 °C(Predicted)
• PKA: 15.01±0.40(Predicted)
• Density: 1.24±0.1 g/cm3(Predicted)

Purity/Quality:

3-O-Benzyl-17β-DihydroEquilin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Estrogen derivative.

Technology Process of 3-O-Benzyl-17β-Dihydro Equilin

There total 2 articles about 3-O-Benzyl-17β-Dihydro Equilin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

17β-dihydroequilin (651-55-8,3563-27-7,23392-56-5,56143-08-9,109715-10-8) + benzoic acid anhydride (93-97-0) → 1,3,5(10),7-estratetraene-3,17β-diol 3-benzoate (26789-44-6)

Guidance literature:

In pyridine;

DOI:10.1016/0039-128X(83)90031-4

Reference yield:

d,l-equilin (474-86-2,24022-60-4) → 1,3,5(10),7-estratetraene-3,17β-diol 3-benzoate (26789-44-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / LiAl(OtBu)3H / tetrahydrofuran / 16 h / Ambient temperature

2: 37 percent / pyridine

With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; pyridine;

DOI:10.1016/0039-128X(83)90031-4

Reference yield: 84.0%

1,3,5(10),7-estratetraene-3,17β-diol 3-benzoate (26789-44-6) → 17β-dihydroequilenin-3-benzoate (88599-97-7)

Guidance literature:

With N-chloro-succinimide; sodium bromide; In methanol; Ambient temperature;

DOI:10.1016/0039-128X(83)90031-4

upstream raw materials:

17β-dihydroequilin

benzoic acid anhydride

d,l-equilin

Downstream raw materials:

17β-dihydroequilenin-3-benzoate

Refernces