tert-butyl 2-(2-oxo-4-phenylbut-3-ynyl)pyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 2-(2-oxo-4-phenylbut-3-ynyl)pyrrolidine-1-carboxylate
• CAS No.: 905717-08-0
• Molecular Formula: C₁₉H₂₃NO₃
• Molecular Weight: 313.397
• Mol file: 905717-08-0.mol

Synonyms:tert-butyl 2-(2-oxo-4-phenylbut-3-ynyl)pyrrolidine-1-carboxylate

Chemical Property of tert-butyl 2-(2-oxo-4-phenylbut-3-ynyl)pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of tert-butyl 2-(2-oxo-4-phenylbut-3-ynyl)pyrrolidine-1-carboxylate

There total 2 articles about tert-butyl 2-(2-oxo-4-phenylbut-3-ynyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-1-(tert-Butoxycarbonyl)pyrrolidine-2-acetic acid (194154-91-1) → tert-butyl 2-(2-oxo-4-phenylbut-3-ynyl)pyrrolidine-1-carboxylate (905717-08-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine; EDCI / CH₂Cl₂ / 2 h / 20 °C

2: tetrahydrofuran / 2 h / 20 °C

With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja0609046

Reference yield:

tert-butyl 2-(2-(methoxy(methyl)amino)-2-oxoethyl)pyrrolidine-1-carboxylate (443797-18-0) + phenylethynylmagnesium bromide (6738-06-3) → tert-butyl 2-(2-oxo-4-phenylbut-3-ynyl)pyrrolidine-1-carboxylate (905717-08-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/ja0609046

Reference yield: 89.0%

tert-butyl 2-(2-oxo-4-phenylbut-3-ynyl)pyrrolidine-1-carboxylate (905717-08-0) → 5-phenyl-2,3,8,8a-tetrahydroindolizin-7(1H)-one

Guidance literature:

tert-butyl 2-(2-oxo-4-phenylbut-3-ynyl)pyrrolidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; for 0.25h;

With methanol; potassium carbonate; for 0.25h;

DOI:10.1021/ja0609046

upstream raw materials:

tert-butyl 2-(2-(methoxy(methyl)amino)-2-oxoethyl)pyrrolidine-1-carboxylate

phenylethynylmagnesium bromide

(+/-)-1-(tert-Butoxycarbonyl)pyrrolidine-2-acetic acid