2-(1-(Tert-butoxycarbonyl)pyrrolidin-2-yl)acetic acid

Base Information

• Chemical Name: 2-(1-(Tert-butoxycarbonyl)pyrrolidin-2-yl)acetic acid
• CAS No.: 194154-91-1
• Molecular Formula: C11H19NO4
• Molecular Weight: 229.276
• Hs Code.: 2933990090
• European Community (EC) Number: 692-183-4,937-368-5
• DSSTox Substance ID: DTXSID60398571
• Mol file: 194154-91-1.mol

Synonyms:194154-91-1;2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)acetic acid;1-Boc-2-pyrrolidineacetic acid;N-Boc-pyrrolidin-2-yl-acetic acid;2-[1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]acetic Acid;2-{1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl}acetic acid;MFCD02179026;2-Pyrrolidineacetic acid, 1-[(1,1-dimethylethoxy)carbonyl]-;2-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester;MFCD06202402;2-(1-BOC-PYRROLIDIN-2-YL)ACETIC ACID;(R)-2-(1-Boc-2-pyrrolidinyl)acetic Acid;Boc-L-|A-homoproline;Boc-|A3-Homopro-OH;BOC-BETA-HOPRO-OH;BOC-D-BETA-HOPRO-OH;SCHEMBL144831;[1-(tert-butoxycarbonyl)pyrrolidin-2-yl]acetic acid;2-(1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)aceticacid;N-Boc-2-pyrrolidineacetic acid;DTXSID60398571;GDWKIRLZWQQMIE-UHFFFAOYSA-N;2-[1-[(2-methylpropan-2-yl)oxy-oxomethyl]-2-pyrrolidinyl]acetic acid;2-[1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]ethanoic acid;2-(1-Boc-2-pyrrolidinyl)acetic Acid;AKOS008105106;AB91469;MF-0703;PB19954;PB26170;SY031962;SY041244;SY042996;Boc-beta-HoPro-OH Boc-L-beta-homoproline;1-Boc-2-pyrrolidineacetic acid, AldrichCPR;CS-0067145;FT-0656104;FT-0684601;FT-0774347;EN300-54217;A20094;A831063;J-505279;tert-butyl 2-carboxymethylpyrrolidine-1-carboxylate;1-(tert-Butoxycarbonyl)-2-(carboxymethyl)pyrrolidine;2-(1-(tert-butoxycarbonyl)-pyrrolidin-2-yl)acetic acid;Z808565786

Chemical Property of 2-(1-(Tert-butoxycarbonyl)pyrrolidin-2-yl)acetic acid

Chemical Property:

• Vapor Pressure: 4.5E-06mmHg at 25°C
• Boiling Point: 357.4oC at 760 mmHg
• Flash Point: 169.9oC
• PSA: 66.84000
• Density: 1.151g/cm3
• LogP: 1.79850
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 229.13140809
• Heavy Atom Count: 16
• Complexity: 282

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-2-pyrrolidineaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCCC1CC(=O)O

Technology Process of 2-(1-(Tert-butoxycarbonyl)pyrrolidin-2-yl)acetic acid

There total 5 articles about 2-(1-(Tert-butoxycarbonyl)pyrrolidin-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.5%

→ (+/-)-1-(tert-Butoxycarbonyl)pyrrolidine-2-acetic acid (194154-91-1)

Guidance literature:

Reference yield:

N-[(1,1-dimethylethoxy)carbonyl]-2-(2-propen-1-yl)pyrrolidine (146337-04-4,144688-83-5) → (+/-)-1-(tert-Butoxycarbonyl)pyrrolidine-2-acetic acid (194154-91-1)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 20 ℃;

DOI:10.1016/j.tetasy.2004.09.022

Reference yield:

tert-butyl 2-(2-ethoxy-2-oxoethyl)pyrrolidine-1-carboxylate (118758-56-8) → (+/-)-1-(tert-Butoxycarbonyl)pyrrolidine-2-acetic acid (194154-91-1)

Guidance literature:

With potassium hydroxide; In methanol;

upstream raw materials:

tert-butyl 2-(2-ethoxy-2-oxoethyl)pyrrolidine-1-carboxylate

N-[(1,1-dimethylethoxy)carbonyl]-2-(2-propen-1-yl)pyrrolidine

homoproline ethyl ester acetate

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl 2-(2-oxo-4-phenylbut-3-ynyl)pyrrolidine-1-carboxylate

2-[3-(4-fluoro-phenyl)-[1,2,4]oxadiazol-5-ylmethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

2-methoxycarbonylmethylpyrrolidine-1-carboxylic acid tert-butyl ester

3-(4-fluoro-phenyl)-5-pyrrolidin-2-ylmethyl-[1,2,4]oxadiazole hydrochloride